Molecular Design of Novel Polymers and Hydrogels Containing Sensitive Temperature-Response

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  • AOYAGI Takao
    Institute of Biomedical Engineering, Tokyo Women's Medical University
  • OKANO Teruo
    Institute of Biomedical Engineering, Tokyo Women's Medical University

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  • 鋭敏な温度応答性を有する新規高分子とハイドロゲルの分子設計
  • エイビン ナ オンド オウトウセイ オ ユウスル シンキ コウブンシ ト ハイドロ ゲル ノ ブンシ セッケイ

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In order for novel copolymers and hydrogels to get a sensitive temperature-response, we assumed that an N-isopropylacrylamide (IPAAm) homopolymer-like structure in polymer chain or networks is assumed to be required. Therefore, two types of copolymer containing IPAAm were newly designed, such as PEG-grafted PIPAAm gels and IPAAm-co-2-carboxyisopropylacrylamide (CIPAAm). PEG-grafted PIPAAm gels showed a similar volume transition to that of PIPAAm homopolymer gels. The transmittance measurement of aqueous solution of IPAAm-co-CIPAAm revealed that phase transition occurred within very narrow temperature range even in pH 9 buffered solution. It is concluded that the repeating structure of isopropylamide groups plays an important role in showing very sensitive response to a temperature change.

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