そらい菌7株およびそらい菌Hawaiian株のイソニコチン酸ヒドラジッド耐性菌,リファンピシン耐性菌の分離培養

DOI Web Site PubMed

書誌事項

タイトル別名
  • Isolation Culture of 7 Strains of Mycobacterium lepraemurium and Isonicotinic Acid Hydrazide or Rifampicin Resistant Hawaiian Strain
  • ソライキン 7 カブ オヨビ ソライキン Hawaiian カブ ノ イソニコ

この論文をさがす

抄録

Seven strains of Mycobacterium lepraemurium (Douglas, Fukuoka-1, Keishicho, Kurume-42, Odessa and Osaka-No. 1 strains) were isolated on the 1% Ogawa yolk medium. These colonies were white yellow, very slow growing and rough at the isolation, but were changed gradually to smooth colony by the successive cultivation. Kurume-42 and Odessa strains were strongly rough type, especially Kurume-42 strain did not change to smooth type untill the 17th generation and became extinct on account of failure of cultivation at the 18th generation. Kurume-42 strain differed from the other 7 strains of murine leprosy bacillus on the characteristic of rough type. All strains secreted coproporphyrine on the medium and coloured to red the medium surface. Many negative tubes were seen every time in the primary isolation culture and some seeded colonies did not grow in the succesive cultivation. All strains are difficult to culture.<br>INH or rifampicin resistant strain was isolated on the 1% Ogawa yolk medium from murine leproma formed with INH or rifampicin resistant Hawaiian strain. Degree of the INH resistant is 16μg/ml and that of rifampicin resistant is 7μg/ml.<br>Seven strains and. INH or rifampicin resistant strain of Hawaiian were cultivated successively for several generations, thereafter these strains were inoculated to mouse. These strains made murine leproma in the injection site. Many globi were observed on the smear preparation of these murine lepromata.

収録刊行物

詳細情報 詳細情報について

問題の指摘

ページトップへ