Rifampicin (RFP)代謝の基礎的研究

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タイトル別名
  • Fundamental Studies on the Metabolism of Rifampicin (RFP)
  • Rifampicin RFP タイシャ ノ キソテキ ケンキュウ エイブン

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Metabolism of RFP and of the representative metabolites was individually compared by tracer method.<br>1. The results were discussed especially concerning the metabolites remaining for long-term iu vivo.<br>2. A new derivative of RFP named as ADP was synthesized. Through the similar reaction between RFP or DARFP and aromatic or alicyclic carboxylic acid chloride the pre-sumable position in RFP skeleton of conjugation such as glucuronide conjugation was discussed.<br>3. In vivo inhibitory effect of protein on the oxidation of RFP series to their respective quinone-forms was examined using cysteine as a model of in vivo SH residue.<br>4. The predominant adsorption of RFP series on IgM of calf serum was concluded.<br>5. The low efficacy of RFPQ and ADP on the growth of leprosy bacilli was concluded by mouse footpad method. The uselessness of DARFP was also presumed.<br>6. The antibacteroidal effects of RFP was compared with those of some antileprosy drugs and the influence of RFP on in vivo enterobacteria was mentioned.<br>7. The relation between these findings and RFP therapy was discussed.

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