Effects of Ultrasound Energy Application on Cardiac Performance in Open-Chest Guinea Pigs An In Vivo Pilot Study

DOI Web Site PubMed 32 References Open Access
  • Kuma Fumiaki
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences
  • Ueda Norihiro
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences
  • Ito Hiroyuki
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences
  • Maruyama Toru
    Institute of Health Science, Kyushu University
  • Kaji Yoshikazu
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences
  • Fujino Takehiko
    Institute of Rheological Function of Foods Co Ltd
  • Harada Mine
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences

Bibliographic Information

Other Title
  • An In Vivo Pilot Study

Search this article

Description

Background Although ultrasound (US) is widely used in cardiology, little is known about the effects of US energy on cardiac performance. This study aimed to investigate the mechanical effects of high-intensity continuous US energy (1.0 MHz with 3 different intensities) on cardiac performance. Methods and Results Either left ventricular (LV) pressure or aortic blood flow (ABF) was evaluated in open-chest guinea pigs (n=30) under surface ECG monitoring. LV systolic pressure and ABF increased significantly (ie, maximum percent increases in these parameters were 2.5%, 3.1% and 7.1% for LV systolic pressure and 9.4%, 4.9% and 8.8% for mean ABF at intensities of 0.06, 0.67 and 2.90 W/cm2, respectively). LV end-diastolic pressure was reduced significantly by US (5.3±0.9 to 4.8±0.8, 5.5 ±1.3 to 4.8±1.0 and 5.8±2.0 to 5.0±1.2 mmHg, respectively), indicating positive inotropic and lusitropic effects and resultant ABF augmentation. Local temperature was not significantly changed. ECG showed neither chronotropic action nor arrhythmogenesis. Conclusions Although the basic mechanisms of these phenomena remain unclear, this pilot study of the short-term effects of US energy on cardiac performance suggests the possibility of physical therapy for heart failure. (Circ J 2006; 70: 1356 - 1361)<br>

Journal

  • Circulation Journal

    Circulation Journal 70 (10), 1356-1361, 2006

    The Japanese Circulation Society

References(32)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top