Prospective Comparison of the 5 Most Popular Risk Scores in Clinical Use for Unselected Patients With Acute Coronary Syndrome

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  • Filipiak Krzysztof J.
    1<sup>st</sup> Chair and Department of Cardiology, Central University Hospital, Medical University of Warsaw
  • Koltowski Lukasz
    1<sup>st</sup> Chair and Department of Cardiology, Central University Hospital, Medical University of Warsaw
  • Grabowski Marcin
    1<sup>st</sup> Chair and Department of Cardiology, Central University Hospital, Medical University of Warsaw
  • Karpinski Grzegorz
    1<sup>st</sup> Chair and Department of Cardiology, Central University Hospital, Medical University of Warsaw
  • Glowczynska Renata
    1<sup>st</sup> Chair and Department of Cardiology, Central University Hospital, Medical University of Warsaw
  • Huczek Zenon
    1<sup>st</sup> Chair and Department of Cardiology, Central University Hospital, Medical University of Warsaw
  • Kochman Janusz
    1<sup>st</sup> Chair and Department of Cardiology, Central University Hospital, Medical University of Warsaw
  • Majstrak Franciszek
    1<sup>st</sup> Chair and Department of Cardiology, Central University Hospital, Medical University of Warsaw
  • Opolski Grzegorz
    1<sup>st</sup> Chair and Department of Cardiology, Central University Hospital, Medical University of Warsaw

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タイトル別名
  • – Basis for Design of the Banach Score –

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Background: A limited number of studies comparing the main risk scores (RS) for acute coronary syndromes (ACS) have been conducted and there is a limited number of long-term observations of unselected patient cohorts evaluated with the various RS. The aim of this study was to validate 5 RS (TIMI STEMI RS, TIMI NSTEMI/UA RS, GRACE RS, SIMPLE RS and ZWOLLE RS) in a Polish population and to develop a new RS that would specifically predict 1-year mortality in the unselected ACS patient cohort. Methods and Results: Single-center ACS registry analysis with 1-year follow-up of 931 patients and prospective comparison of 5 RS was conducted. Creation of an RS was attempted. Risk factors were evaluated in a multivariate logistic regression model. The predictive value of the model was assessed with evaluation of the area under curve (AUC) in receiver-operating characteristic analysis. Twelve independent factors influencing 1-year mortality were identified and of them, clerking, physical findings on admission, first ECG and myocardial necrosis markers demonstrated sufficiently high predictive value. All 5 RS were successfully validated in the target registry and although they all displayed high predictive value, the TIMI RS STEMI (AUC=0.84) and GRACE RS (AUC=0.84) proved superior. Conclusions: The developed Banach score offers both high goodness-of-fit and predictive value and may be used irrespective of ACS type. (Circ J 2011; 75: 167-173)<br>

収録刊行物

  • Circulation Journal

    Circulation Journal 75 (1), 167-173, 2011

    一般社団法人 日本循環器学会

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