Cyclophilin A Is a Promising Predictor of Coronary Artery Disease

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  • Satoh Kimio
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
  • Fukumoto Yoshihiro
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
  • Sugimura Koichiro
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
  • Miura Yutaka
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
  • Aoki Tatsuo
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
  • Nochioka Kotaro
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
  • Tatebe Shunsuke
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
  • Miyamichi-Yamamoto Saori
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
  • Shimizu Toru
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
  • Osaki Shizuka
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
  • Takagi Yusuke
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
  • Tsuburaya Ryuji
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
  • Ito Yoshitaka
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
  • Matsumoto Yasuharu
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
  • Nakayama Masaharu
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
  • Takeda Morihiko
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
  • Takahashi Jun
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
  • Ito Kenta
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
  • Yasuda Satoshi
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
  • Shimokawa Hiroaki
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine

書誌事項

タイトル別名
  • Plasma Cyclophilin A Is a Novel Biomarker for Coronary Artery Disease

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説明

Background: Oxidative stress induces secretion of cyclophilin A (CyPA) from vascular smooth muscle cells and it plays a crucial role in the pathogenesis of atherosclerosis in mice. Therefore, we tested our hypothesis that plasma CyPA levels are increased in patients with coronary artery diseases (CAD). Methods and Results: In 320 consecutive patients undergoing coronary angiography, we examined the relationship between plasma CyPA levels and the severity of CAD. We measured plasma CyPA by an immunoassay based on the sandwich technique. Plasma CyPA levels were significantly higher in patients with significant coronary stenosis compared to those without it (P<0.001). A positive correlation was noted between plasma CyPA levels and significant coronary stenosis. The average number of stenotic coronary arteries and the need for coronary intervention were significantly increased in the quartiles of higher CyPA levels (both P<0.001). Indeed, the plasma CyPA level significantly correlated with the presence of CAD (adjusted odds ratio for CAD, 6.20; 95% confidence interval, 3.14–12.27; P<0.001). Interestingly, plasma levels of CyPA increased according to the number of atherosclerotic risk factors, all of which induce oxidative stress. Furthermore, plasma levels of CyPA significantly reduced after medical treatment of risk factors. Finally, CyPA was strongly expressed in coronary atherosclerotic plaque in patients with myocardial infarction. Conclusions: Plasma CyPA level is a novel biomarker for oxidative stress and CAD in humans.  (Circ J 2013; 77: 447–455)<br>

収録刊行物

  • Circulation Journal

    Circulation Journal 77 (2), 447-455, 2013

    一般社団法人 日本循環器学会

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