Assessment by Optical Coherence Tomography of Stent Struts Across Side Branch

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  • Liu Yong
    Department of Cardiovascular Medicine, Wakayama Medical University
  • Imanishi Toshio
    Department of Cardiovascular Medicine, Wakayama Medical University
  • Kubo Takashi
    Department of Cardiovascular Medicine, Wakayama Medical University
  • Tanaka Atsushi
    Department of Cardiovascular Medicine, Wakayama Medical University
  • Kitabata Hironori
    Department of Cardiovascular Medicine, Wakayama Medical University
  • Tanimoto Takashi
    Department of Cardiovascular Medicine, Wakayama Medical University
  • Ino Yasushi
    Department of Cardiovascular Medicine, Wakayama Medical University
  • Ikejima Hideyuki
    Department of Cardiovascular Medicine, Wakayama Medical University
  • Tsujioka Hiroto
    Department of Cardiovascular Medicine, Wakayama Medical University
  • Komukai Kenichi
    Department of Cardiovascular Medicine, Wakayama Medical University
  • Ishibashi Kohei
    Department of Cardiovascular Medicine, Wakayama Medical University
  • Kashiwagi Manabu
    Department of Cardiovascular Medicine, Wakayama Medical University
  • Ozaki Yuichi
    Department of Cardiovascular Medicine, Wakayama Medical University
  • Hirata Kumiko
    Department of Cardiovascular Medicine, Wakayama Medical University
  • Mizukoshi Masato
    Department of Cardiovascular Medicine, Wakayama Medical University
  • Akasaka Takashi
    Department of Cardiovascular Medicine, Wakayama Medical University

書誌事項

タイトル別名
  • – Comparison of Bare-Metal Stents and Drug-Eluting Stents –

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説明

Background: Late stent thrombosis (LST) after drug-eluting stent (DES) implantation is a major clinical problem that has not been fully explained. Incomplete neointimal coverage of stent struts is an important morphometric predictor of LST, which may be associated with impaired healing and the absence of full coverage of struts at branch-point ostia. Optical coherence tomography (OCT) was performed to compare 3 types of stents placed across side branches. Methods and Results: At 9-month follow-up, the neointimal coverage of the struts of 58 stents across a side branch was measured by OCT (bare metal (BMS), n=20; sirolimus-eluting (SES), n=23; paclitaxel-eluting (PES), n=15). According to the diameter ratio of side branch to main vessel, the side branches were classified as either large (ratio >0.33) or small (ratio ≤0.33). BMS had the lowest frequency of uncovered struts (29.4%) and the greatest neointimal thickness on the struts (123±33μm). Neointimal thickness on the struts was less for SES than for PES (72±16 vs. 91±22μm, P=0.009), but there was no difference in the frequency of uncovered struts (66.1% vs. 58.6%, P=0.493). For large side branches, the frequency of uncovered struts was greater than in the small group for SES (87.5% vs. 40.7%, P=0.0002) and PES (83.3% vs. 18.2%; P=0.0013); there was no significant difference for BMS (43.8% vs. 16.7%, P=0.138). Conclusions: Neointimal coverage on struts across a side branch was less frequently observed in DES than in BMS, particularly in large side branches. (Circ J 2011; 75: 106-112)<br>

収録刊行物

  • Circulation Journal

    Circulation Journal 75 (1), 106-112, 2011

    一般社団法人 日本循環器学会

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