Allelic Variants of Upstream Transcription Factor 1 Associate With Carotid Artery Intima-Media Thickness The Cardiovascular Risk in Young Finns Study

DOI Web Site 2 Citations 110 References
  • Collings Auni
    Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital and Tampere University Medical School
  • Höyssä Salla
    Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital and Tampere University Medical School
  • Fan Meng
    Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital and Tampere University Medical School
  • Kähönen Mika
    Department of Clinical Physiology, Tampere University Hospital
  • Hutri-Kähönen Nina
    Department of Paediatrics, Tampere University Hospital
  • Marniemi Jukka
    Department of Health and Functional Capacity, Population Research Laboratory, National Public Health Institute
  • Juonala Markus
    Research Centre of Applied and Preventive Cardiovascular Medicine
  • Viikari Jorma S. A.
    Department of Medicine, University of Turku
  • Raitakari Olli T.
    Department of Clinical Physiology, University of Turku
  • Lehtimäki Terho J.
    Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital and Tampere University Medical School

Bibliographic Information

Other Title
  • The Cardiovascular Risk in Young Finns Study

Search this article

Description

Background Polymorphisms of the upstream transcription factor 1 (USF1) have been associated with familial combined hyperlipidemia and coronary heart disease. The impact of this gene on subclinical atherosclerosis is unknown. Associations of 3 allelic variants of the USF1 gene and their haplotypes with carotid artery intima - media thickness (IMT), carotid artery compliance (CAC) and brachial artery flow mediated dilatation (FMD) were studied in a population of Finnish healthy young adults. Methods and Results The study population comprised 2,281 individuals participating in the Cardiovascular Risk in Young Finns study. IMT, CAC and FMD values were measured by ultrasound examination. Genotypes were analysed using the 5' nuclease assay. A significant difference in IMT was found for usf1s1 (rs3737787) and usf1s8 (rs2516838) genotypes (p-values 0.046 and 0.021, respectively). Moreover, there was a significant difference between groups in haplotype 1 and haplotype 2 for IMT (p-values 0.011 and 0.028 respectively). In multivariate stepwise linear regression models adjusted by age, sex, body mass index, systolic and diastolic blood pressures, smoking, C-reactive protein, glucose, high- and low-density lipoprotein-cholesterols and triglycerides there were significant associations for the usf1s1 minor genotype AA to predict low IMT (p=0.038) and usf1s8 minor genotype GG to predict high IMT (p=0.003). There was also a significant association for haplotype 2 to predict low IMT in the otherwise similar multivariate model (p=0.006). No associations were found for polymorphisms and CAC, FMD or serum lipids. Conclusions The rs2516838 and rs3737787 polymorphisms of USF1 influence the carotid artery IMT, which is a new finding. (Circ J 2008; 72: 1158 -1164)<br>

Journal

  • Circulation Journal

    Circulation Journal 72 (7), 1158-1164, 2008

    The Japanese Circulation Society

Citations (2)*help

See more

References(110)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top