LOX-1 The Multifunctional Receptor Underlying Cardiovascular Dysfunction

DOI Web Site 被引用文献14件 参考文献132件
  • Ogura Sayoko
    Department of Vascular Physiology, National Cardiovascular Center
  • Kakino Akemi
    Department of Vascular Physiology, National Cardiovascular Center
  • Sato Yuko
    Department of Vascular Physiology, National Cardiovascular Center
  • Fujita Yoshiko
    Department of Vascular Physiology, National Cardiovascular Center
  • Iwamoto Shin
    Department of Vascular Physiology, National Cardiovascular Center
  • Otsui Kazunori
    Department of Vascular Physiology, National Cardiovascular Center
  • Yoshimoto Ryo
    Department of Vascular Physiology, National Cardiovascular Center
  • Sawamura Tatsuya
    Department of Vascular Physiology, National Cardiovascular Center

書誌事項

タイトル別名
  • The Multifunctional Receptor Underlying Cardiovascular Dysfunction

この論文をさがす

説明

Oxidatively modified low-density lipoprotein (oxLDL) is implicated in the pathogenesis of atherosclerosis. Endothelial dysfunction is the initial change in the vascular wall that induces morphological changes for atheroma-formation. Lectin-like oxidized LDL receptor-1 (LOX-1) was identified as the receptor for oxLDL that was thought to be a major cause of endothelial dysfunction. LOX-1 has been demonstrated to contribute not only to endothelial dysfunction, but also to atherosclerotic-plaque formation, myocardial infarction and intimal thickening after balloon injury. Recent findings on the genetics of LOX-1 and the methodology to detect it and its ligands would further facilitate the examination of the receptor's pathophysiological contribution in atherosclerosis. Furthermore, LOX-1-related tools might open new gateways from diagnosis to therapeutics for cardiovascular diseases. (Circ J 2009; 73: 1993-1999)<br>

収録刊行物

  • Circulation Journal

    Circulation Journal 73 (11), 1993-1999, 2009

    一般社団法人 日本循環器学会

被引用文献 (14)*注記

もっと見る

参考文献 (132)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ