Low risk for arrhythmic events in asymptomatic patients with drug-induced type 1 ECG. Do patients with drug-induced Brugada type ECG have poor prognosis? (con)
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- Nishizaki Mitsuhiro
- Department of Cardiology, Yokohama Minami Kyosai Hospital
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- Sakurada Harumizu
- Department of Cardiology, Tokyo Metropolitan Hiroo Hospital
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- Yamawake Noriyoshi
- Department of Cardiology, Yokohama Minami Kyosai Hospital
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- Ueda-Tatsumoto Akiko
- Department of Cardiology, Tokyo Metropolitan Hiroo Hospital
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- Hiraoka Masayasu
- Tokyo Medical and Dental University
書誌事項
- タイトル別名
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- Low Risk for Arrhythmic Events in Asymptomatic Patients With Drug-Induced Type 1 ECG
- – Do Patients With Drug-Induced Brugada Type ECG Have Poor Prognosis? (Con) –
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説明
The type 1 ST-segment elevation is diagnostic for Brugada syndrome (BS) and its presence may sometimes be associated with a high risk of arrhythmic events. The type 1 ECG is also known to be unmasked by administration of sodium-channel blockers in equivocal or suspected cases of BS, and the drug-challenge test is frequently used in the diagnostic approach. In large cohort studies the spontaneous appearance of the type 1 ECG with symptoms of aborted sudden death or unexplained syncope are indicative of a poor prognosis for patients with BS compared with not having clinical symptoms. Therefore, the spontaneous type 1 ECG appears to represent an important predictive sign for cardiac events. It is unknown, however, whether or not the drug-induced type 1 ECG is as useful as the spontaneous type 1 for predicting cardiac events in asymptomatic subjects showing non-type 1 ECG. Review of the literature for large cohort studies indicates that there is a low incidence of arrhythmic events in asymptomatic patients with either the spontaneous or drug-induced type 1 ECG compared with symptomatic subjects, and the drug-induced type1 ECG in asymptomatic patients does not add to an increase in arrhythmic risk. Therefore, drug testing to unmask the type 1 ECG in asymptomatic patients with a non-type 1 BS ECG does not have an additional value for risk stratification of cardiac events, although it might be useful in symptomatic patients showing only the non-type 1 ECG. (Circ J 2010; 74: 2464-2473)<br>
収録刊行物
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- Circulation Journal
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Circulation Journal 74 (11), 2464-2473, 2010
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390001205103328896
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- NII論文ID
- 10026973331
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- PubMed
- 20962432
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可
