Efficacy of continuous low-dose hANP administration in patients undergoing emergency coronary artery bypass grafting for acute coronary syndrome
-
- Sezai Akira
- Department of Cardiovascular Surgery, Nihon University School of Medicine
-
- Hata Mitsumasa
- Department of Cardiovascular Surgery, Nihon University School of Medicine
-
- Wakui Shinji
- Department of Cardiovascular Surgery, Nihon University School of Medicine
-
- Niino Tetsuya
- Department of Cardiovascular Surgery, Nihon University School of Medicine
-
- Takayama Tadateru
- Department of Cardiology, Nihon University School of Medicine
-
- Hirayama Atsushi
- Department of Cardiology, Nihon University School of Medicine
-
- Saito Satoshi
- Department of Cardiology, Nihon University School of Medicine
-
- Minami Kazutomo
- Department of Cardiovascular Surgery, Nihon University School of Medicine
書誌事項
- タイトル別名
-
- Efficacy of Continuous Low-Dose hANP Administration in Patients Undergoing Emergent Coronary Artery Bypass Grafting for Acute Coronary Syndrome
この論文をさがす
説明
Background Low-dose continuous human atrial natriuretic peptide (hANP) administration during cardiac surgery has been reported on previously. In the present study, the efficacy of the therapy during emergent coronary artery bypass grafting (CABG) for acute coronary syndrome (ACS) is investigated. Methods and Results One hundred and twenty-four patients patients undergoing emergent CABG for ACS were divided into 2 groups; a group receiving administration of hANP (hANP group) and a group not receiving hANP infusion (non-hANP group). The postoperative peak levels of creatine kinase-MB were significantly lower in the hANP group as compared with those in the non-hANP group. The incidence of postoperative arrhythmias was also significantly lower in the hANP group as compared with that in the non-hANP group. The postoperative brain natriuretic peptide was significantly lower in the hANP group as compared with that in the non-hANP group until 1 year after the operation. The free-rate of cardiac events after the operation was also significantly higher in the hANP group as compared with that in the non-hANP group. Conclusions It is therefore considered that hANP might not only be effective for overcoming some major shortcomings of cardiopulmonary bypass, but also might be effective to attenuate ischemia-reperfusion injury, protect the myocardium, have an anti-arrhythmic effect, and suppress left ventricular remodeling. (Circ J 2007; 71: 1401 - 1407)<br>
収録刊行物
-
- Circulation Journal
-
Circulation Journal 71 (9), 1401-1407, 2007
一般社団法人 日本循環器学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001205103632640
-
- NII論文ID
- 110006399685
-
- NII書誌ID
- AA11591968
-
- COI
- 1:CAS:528:DC%2BD2sXhtFSltbrK
-
- ISSN
- 13474820
- 13469843
-
- PubMed
- 17721018
-
- 本文言語コード
- en
-
- 資料種別
- journal article
-
- データソース種別
-
- JaLC
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
-
- 抄録ライセンスフラグ
- 使用不可