Administration of Atrial Natriuretic Peptide Attenuates Reperfusion Phenomena and Preserves Left Ventricular Regional Wall Motion After Direct Coronary Angioplasty for Acute Myocardial Infarction

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  • Kuga Hideyo
    Department of Cardiology and Pneumology, Dokkyo University School of Medicine
  • Ogawa Kenichi
    Department of Cardiology and Pneumology, Dokkyo University School of Medicine
  • Oida Akitugu
    Department of Cardiology and Pneumology, Dokkyo University School of Medicine
  • Taguchi Isao
    Department of Cardiology and Pneumology, Dokkyo University School of Medicine
  • Nakatsugawa Masatoshi
    Department of Cardiology and Pneumology, Dokkyo University School of Medicine
  • Hoshi Toshiyasu
    Department of Cardiology and Pneumology, Dokkyo University School of Medicine
  • Sugimura Hiroyasu
    Department of Cardiology and Pneumology, Dokkyo University School of Medicine
  • Abe Shichirou
    Department of Cardiology and Pneumology, Dokkyo University School of Medicine
  • Kaneko Noboru
    Department of Cardiology and Pneumology, Dokkyo University School of Medicine

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Description

To evaluate the effects of synthetic human atrial natriuretic peptide (hANP) on myocardial reperfusion injury and left ventricular remodeling, 19 patients within 12 h of a first attack of anterior myocardial infarction (AMI) underwent intracoronary injection of 25 μg of hANP immediately after coronary angioplasty, combined with intravenous infusion of 0.025 μg · kg-1 · min-1 of hANP initiated on admission for 1 week (hANP group); 18 similar patients had saline administered (control group). The incidences of premature ventricular contraction, ventricular tachycardia and/or fibrillation in the hANP group were significantly less than in the control group after coronary angioplasty. Left ventricular ejection fraction was significantly greater and left ventricular end-diastolic volume index was significantly smaller 6 months after coronary angioplasty. Left ventricular regional wall motion of the infarcted segments significantly increased. Thus, hANP remarkably suppressed reperfusion phenomena and preserved left ventricular function through improvement of regional wall motion of the infarcted segments after coronary angioplasty. (Circ J 2003; 67: 443 - 448)<br>

Journal

  • Circulation Journal

    Circulation Journal 67 (5), 443-448, 2003

    The Japanese Circulation Society

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