Intra-Individual Variability of High-Sensitivity C-Reactive Protein Age-Related Variation Over Time in Japanese Subjects
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- Nasermoaddeli Ali
- Department of Welfare Promotion and Epidemiology, Faculty of Medicine, University of Toyama
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- Sekine Michikazu
- Department of Welfare Promotion and Epidemiology, Faculty of Medicine, University of Toyama
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- Kagamimori Sadanobu
- Department of Welfare Promotion and Epidemiology, Faculty of Medicine, University of Toyama
書誌事項
- タイトル別名
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- Age-Related Variation Over Time in Japanese Subjects
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説明
Background Prospective studies have demonstrated a direct association between the baseline level of high-sensitivity C-reactive protein (hsCRP) and the risk of developing cardiovascular disease. The potential for hsCRP variability during the follow-up interval is of great interest, so the repeatability of measurements of hsCRP in men and women, and in different age groups, was investigated in the present study. Methods and Results The measurement of hsCRP was performed in 899 male and 780 female Japanese civil servants aged 18-60 years in the spring of 2004 and 2005. Within-subject repeatability and intra-class correlation coefficient of reliability were used to characterize the variation in measurements. Error of the measurement process was negligible, as the analytical variance was 0.0003 [ln(mg/L)] [ln(mg/L)] with a reliability coefficient of 0.997. In contrast, the within-subject variation of hsCRP was considerable with a reliability coefficient of 0.61 in both sexes and repeatability coefficients of 5.25 and 5.38 in men and women, respectively. The variation differed with age, especially in women, as less variation was observed in subjects over 40 years of age during the follow-up interval. Conclusions The results suggest that a single measurement of hsCRP is subject to considerable but equal within-subject variation over time in men and women, and this variation differs among the age groups, which may affect the risk assessment of hsCRP in association with future cardiovascular events. (Circ J 2006; 70: 559 - 563)<br>
収録刊行物
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- Circulation Journal
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Circulation Journal 70 (5), 559-563, 2006
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390001205104258944
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- NII論文ID
- 110004720674
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
- http://id.crossref.org/issn/13469843
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可