Predictors of International Normalized Ratio Variability in Patients With Atrial Fibrillation Under Warfarin Therapy
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- Numao Yoshimi
- Department of Cardiovascular Medicine, The Cardiovascular Institute
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- Suzuki Shinya
- Department of Cardiovascular Medicine, The Cardiovascular Institute
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- Arita Takuto
- Department of Cardiovascular Medicine, The Cardiovascular Institute
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- Yagi Naoharu
- Department of Cardiovascular Medicine, The Cardiovascular Institute
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- Otsuka Takayuki
- Department of Cardiovascular Medicine, The Cardiovascular Institute
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- Sagara Koichi
- Department of Cardiovascular Medicine, The Cardiovascular Institute
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- Semba Hiroaki
- Department of Cardiovascular Medicine, The Cardiovascular Institute
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- Sasaki Kenichi
- Department of Cardiovascular Surgery, The Cardiovascular Institute
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- Kano Hiroto
- Department of Cardiovascular Medicine, The Cardiovascular Institute
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- Matsuno Shunsuke
- Department of Cardiovascular Medicine, The Cardiovascular Institute
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- Kato Yuko
- Department of Cardiovascular Medicine, The Cardiovascular Institute
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- Uejima Tokuhisa
- Department of Cardiovascular Medicine, The Cardiovascular Institute
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- Oikawa Yuji
- Department of Cardiovascular Medicine, The Cardiovascular Institute
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- Nagashima Kazuyuki
- Department of Cardiovascular Medicine, The Cardiovascular Institute
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- Kirigaya Hajime
- Department of Cardiovascular Medicine, The Cardiovascular Institute
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- Kunihara Takashi
- Department of Cardiovascular Surgery, The Cardiovascular Institute
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- Yajima Junji
- Department of Cardiovascular Medicine, The Cardiovascular Institute
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- Aizawa Tadanori
- Department of Cardiovascular Medicine, The Cardiovascular Institute
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- Yamashita Takeshi
- Department of Cardiovascular Medicine, The Cardiovascular Institute
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<p>Background:Variability in the international normalized ratio (INR) of prothrombin time has been suggested to be related to outcome in patients with atrial fibrillation (AF) under warfarin therapy, but its determinants remain unclear.</p><p>Methods and Results:The study population consisted of 626 AF patients under warfarin therapy in the Shinken Database (n=22,230). INR variability was calculated by Fihn’s method. Determinants of high log INR variability (defined as over mean+standard deviation) were determined by logistic regression analyses. Symptomatic heart failure (odds ratio [OR] 3.974, 95% confidence interval [CI] 2.510–6.292), older age (≥75 years old; OR 2.984, 95% CI 1.844–4.826) and severe renal dysfunction (eGFR <30 mL/min/1.73 m2; OR 3.918, 95% CI 1.742–8.813) were identified as independent predictors of high INR variability on multivariate logistic regression analysis.</p><p>Conclusions:The determinants of INR variability in AF patients under warfarin therapy could assist Japanese clinicians in identifying patients likely to show unstable warfarin control irrespective of the definition of the target INR range.</p>
収録刊行物
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- Circulation Journal
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Circulation Journal 82 (1), 39-45, 2018
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390001205106470016
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- NII論文ID
- 130006281938
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL書誌ID
- 028734566
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- PubMed
- 28638002
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可