書誌事項
- タイトル別名
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- Enumerating Minimal Active Metabolic Pathways by Model Generation
説明
In systems biology, identifying vital functions like glycolysis from a given metabolic pathway is important to understand living organisms. In this paper, we particularly focus on the problem of enumerating minimal active pathways producing target metabolites from source metabolites. We represent the problem in propositional formulas and solve it through minimal model generation. An advantage of our method is that each solution satisfies qualitative laws of biochemical reactions. Moreover, we can calculate such solutions for a cellular scale metabolic pathway within a few seconds. In experiments, we have applied our method to a whole Escherichia coli metabolic pathway. As a result, we found a minimal set of reactions corresponding to the conventional glycolysis pathway described in a biological database EcoCyc.
収録刊行物
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- 人工知能学会論文誌
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人工知能学会論文誌 27 (3), 204-212, 2012
一般社団法人 人工知能学会
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詳細情報 詳細情報について
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- CRID
- 1390001205106718464
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- NII論文ID
- 130001878758
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- BIBCODE
- 2012TJSAI..27..204S
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- ISSN
- 13468030
- 13460714
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可