Age- and Sex-Specific Burden of Cardiovascular Disease Attributable to 5 Major and Modifiable Risk Factors in 10 Asian Countries of the Western Pacific Region

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  • Huxley Rachel R.
    School of Public Health, University of Queensland The George Institute for Global Health, University of Sydney
  • Hirakawa Yoichiro
    The George Institute for Global Health, University of Sydney
  • Hussain Mohammad Akhtar
    School of Public Health, University of Queensland
  • Aekplakorn Wichai
    Department of Community Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University
  • Wang Xin
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht
  • Peters Sanne AE
    The George Institute for Global Health, Nuffield Department for Population Health, University of Oxford
  • Mamun Abdullah
    School of Public Health, University of Queensland
  • Woodward Mark
    The George Institute for Global Health, University of Sydney The George Institute for Global Health, Nuffield Department for Population Health, University of Oxford

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Abstract

Cardiovascular disease (CVD) is the leading cause of mortality worldwide, causing an estimated 18 million deaths annually. Much of the burden of CVD resides in lower- and middle-income countries, particularly those Asian countries comprising the Western Pacific Region. Epidemiological studies have convincingly shown that up to 90% of all CVD can be explained by a small number of modifiable risk factors, including blood pressure, smoking, diabetes, total cholesterol and excess body weight. However, the relationship between these risk factors and coronary artery disease and stroke often differ by age and sex, and yet these differences are often overlooked in burden of disease estimations. As such, that can result in either an over- or under-estimation of the disease burden in specific population subgroups, which may affect resource allocation of healthcare. In this review, we derive the most reliable and previously unpublished estimates of the age- and sex-specific burden of vascular disease attributable to the aforementioned risk factors for 10 of the most populous Asian countries in the Western Pacific Region. Understanding how the burden of vascular disease is distributed within and between populations is crucial for developing appropriate health policies and effective treatment strategies, particularly in resource-poor settings. (Circ J 2015; 79: 1662–1674)

Journal

  • Circulation Journal

    Circulation Journal 79 (8), 1662-1674, 2015

    The Japanese Circulation Society

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