FOCUS REVIEWS ON HEART FAILURE : Diastolic Dysfunction : Potential New Diagnostics and Therapies

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  • Jeong Euy-Myoung
    Cardiovascular Research Center and Cardiovascular Institute of Lifespan, The Warren Alpert Medical School, Brown University
  • Dudley Jr Samuel C.
    Cardiovascular Research Center and Cardiovascular Institute of Lifespan, The Warren Alpert Medical School, Brown University

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タイトル別名
  • Diastolic Dysfunction
  • – Potential New Diagnostics and Therapies –

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説明

Despite the growing number of patients affected, the understanding of diastolic dysfunction and heart failure with preserved ejection fraction (HFpEF) is still poor. Clinical trials, largely based on successful treatments for systolic heart failure, have been disappointing, suggesting that HFpEF has a different pathology to that of systolic dysfunction. In this review, general concepts, epidemiology, diagnosis, and treatment of diastolic dysfunction are summarized, with an emphasis on new experiments suggesting that oxidative stress plays a crucial role in the pathogenesis of at least some forms of the disease. This observation has lead to potential new diagnostics and therapeutics for diastolic dysfunction and heart failure caused by diastolic dysfunction. (Circ J 2015; 79: 470–477)

収録刊行物

  • Circulation Journal

    Circulation Journal 79 (3), 470-477, 2015

    一般社団法人 日本循環器学会

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