Augmentation Index Does Not Reflect Risk of Coronary Artery Disease in Elderly Patients

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  • Hayashi Shuji
    Ultrasound Examination Center, Tokushima University Hospital
  • Yamada Hirotsugu
    Department of Cardiovascular Medicine, Tokushima University Hospital
  • Bando Mika
    Department of Cardiovascular Medicine, Tokushima University Hospital
  • Hotchi Junko
    Department of Cardiovascular Medicine, Tokushima University Hospital
  • Ise Takayuki
    Department of Cardiovascular Medicine, Tokushima University Hospital
  • Yamaguchi Koji
    Department of Cardiovascular Medicine, Tokushima University Hospital
  • Iwase Takashi
    Department of Cardiovascular Medicine, Tokushima University Hospital
  • Soeki Takeshi
    Department of Cardiovascular Medicine, Tokushima University Hospital
  • Wakatsuki Tetsuzo
    Department of Cardiovascular Medicine, Tokushima University Hospital
  • Tamaki Toshiaki
    Department of Pharmacology, Institute of Health Biosciences, University of Tokushima Graduate School
  • Sata Masataka
    Department of Cardiovascular Medicine, Tokushima University Hospital

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Background: Augmentation index (AI) has been used as a clinical index of arterial stiffness and has been reported to be an independent predictor of cardiovascular events, but some investigators have reported that AI is not a useful marker to identify coronary artery disease (CAD) in elderly patients. The majority of CAD patients are elderly people, therefore the aim of this study was to examine whether AI is a useful marker to identify the risk of CAD. Methods and Results: A total of 120 patients (69±10 years of age; 83 male) who underwent cardiac catheterization for suspected CAD were enrolled. Invasive central blood pressure (BP) was measured using a fluid-filled catheter. Non-invasive AI was calculated by the SphygmoCor (AtCor Medical) system at the end of catheterization. Subjects consisted of 99 patients with CAD and 21 patients without CAD. There was no significant difference in AI between the CAD and the non-CAD groups (24±10 vs. 24±14%). Non-invasive systolic central BP was lower than the invasive systolic central BP (115±18 vs. 130±23mmHg, P<0.001) in all patients. Non-invasive diastolic central BP was greater than the invasive diastolic central BP (67±10 vs. 63±10mmHg, P<0.001). Conclusions: In elderly patients, AI may not be a useful marker to identify CAD.  (Circ J 2014; 78: 1176–1182)<br>

収録刊行物

  • Circulation Journal

    Circulation Journal 78 (5), 1176-1182, 2014

    一般社団法人 日本循環器学会

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