Enhancement of Endothelial Function Inhibits Left Atrial Thrombi Development in an Animal Model of Spontaneous Left Atrial Thrombosis
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- Mawatari Kazuaki
- Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School Department of Preventive Environment and Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
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- Yoshioka Emiko
- Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
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- Toda Satomi
- Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
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- Yasui Sonoko
- Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School Department of Therapeutic Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
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- Furukawa Hiroko
- Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
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- Shimohata Takaaki
- Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School Department of Preventive Environment and Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
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- Ohnishi Takamasa
- Department of Nutrition Management, Faculty of Health Science, Hyogo University
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- Morishima Masaki
- Department of Cardiovascular Sciences, Oita University School of Medicine
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- Harada Nagakatsu
- Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
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- Takahashi Akira
- Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School Department of Preventive Environment and Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
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- Sakaue Hiroshi
- Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
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- Nakaya Yutaka
- Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
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Background:Left atrial (LA) thrombosis is an important cause of systemic embolization. The SPORTS rat model of LA thrombi (Spontaneously-Running Tokushima-Shikoku), which have a unique characteristic of high voluntary wheel running, was previously established. The aim of the present study was to investigate how SPORTS rats develop LA thrombi.Methods and Results:Nitric oxide (NO) produced from cardiovascular endothelial cells plays an important protective role in the local regulation of blood flow, vascular tone, and platelet aggregation. No evidence of atrial fibrillation or hypercoagulability in SPORTS rats regardless of age was found; however, SPORTS rats demonstrated endothelial dysfunction and a decrease of NO production from a young age. In addition, endothelial NO synthase activity was significantly decreased in the LA and thoracic aorta endothelia of SPORTS rats. While voluntary wheel running was able to intermittently increase NO levels, running did not statistically decrease the incidence of LA thrombi at autopsy. However, L-arginine treatment significantly increased NO production and provided protection from the development of LA thrombi in SPORTS rats.Conclusions:They present study results indicate that NO has an important role in the development of LA thrombus, and endothelia pathways could provide new targets of therapy to prevent LA thrombosis. (Circ J 2014; 78: 1980–1988)
収録刊行物
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- Circulation Journal
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Circulation Journal 78 (8), 1980-1988, 2014
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390001205107584512
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- NII論文ID
- 130004427936
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- NII書誌ID
- AA11591968
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- COI
- 1:STN:280:DC%2BC2cjlslKltA%3D%3D
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- ISSN
- 13474820
- 13469843
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- NDL書誌ID
- 025599435
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- PubMed
- 24859498
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可