Long-Term Clinical Outcomes of True and Non-True Bifurcation Lesions According to Medina Classification – Results From the COBIS (COronary BIfurcation Stent) II Registry –

  • Park Taek Kyu
    Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine
  • Park Yong Hwan
    Samsung Changwon Hospital, Sungkyunkwan University School of Medicine
  • Song Young Bin
    Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine
  • Oh Ju Hyeon
    Samsung Changwon Hospital, Sungkyunkwan University School of Medicine
  • Chun Woo Jung
    Samsung Changwon Hospital, Sungkyunkwan University School of Medicine
  • Kang Gu Hyun
    Samsung Changwon Hospital, Sungkyunkwan University School of Medicine
  • Jang Woo Jin
    Samsung Changwon Hospital, Sungkyunkwan University School of Medicine
  • Hahn Joo-Yong
    Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine
  • Yang Jeong Hoon
    Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine
  • Choi Seung-Hyuk
    Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine
  • Choi Jin-Ho
    Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine
  • Lee Sang Hoon
    Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine
  • Jeong Myung-Ho
    Chonnam National University Hospital
  • Kim Hyo-Soo
    Seoul National University Hospital
  • Lee Jae-Hwan
    Chungnam National University Hospital
  • Yu Cheol Woong
    Korea University Anam Hospital
  • Rha Seung Woon
    Korea University Guro Hospital
  • Jang Yangsoo
    Yonsei University Severance Hospital
  • Yoon Jung Han
    Wonju Christian Hospital
  • Tahk Seung-Jea
    Ajou University Hospital
  • Seung Ki Bae
    Catholic University Kangnam St. Mary’s Hospital
  • Park Jong-Seon
    and Yeungnam University Hospital
  • Gwon Hyeon-Cheol
    Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine

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Background:Little is known about the clinical outcomes of patients with different types of coronary bifurcation lesions. We sought to compare long-term clinical outcomes of patients with true or non-true bifurcation lesions who underwent percutaneous coronary intervention.Methods and Results:We compared major adverse cardiac events (MACE: cardiac death, myocardial infarction [MI], or target lesion revascularization) between 1,502 patients with true bifurcation lesions (51.8%) and 1,395 with non-true bifurcation lesions (48.2%). True bifurcation lesions were defined as Medina classification (1.1.1), (1.0.1), or (0.1.1) lesions. During a median follow-up of 36 months, MACE occurred in 296 (10.2%) patients. Patients with true bifurcation lesions had a significantly higher risk of MACE than those with non-true bifurcation lesions (HR 1.39; 95% CI 1.08–1.80; P=0.01). Among true bifurcation lesions, Medina (1.1.1) and (0.1.1) were associated with a higher risk of cardiac death or MI than Medina (1.0.1) (HR 4.15; 95% CI 1.01–17.1; P=0.05). During the procedure, side branch occlusion occurred more frequently in Medina (1.1.1) and (1.0.1) than Medina (0.1.1) lesions (11.5% vs. 7.4%, P=0.03).Conclusions:Patients with true bifurcation lesions had worse clinical outcomes than those with non-true bifurcation lesions. Procedural and long-term clinical outcomes differed according to the type of bifurcation lesion. These findings should be considered in future bifurcation studies. (Circ J 2015; 79: 1954–1962)

収録刊行物

  • Circulation Journal

    Circulation Journal 79 (9), 1954-1962, 2015

    一般社団法人 日本循環器学会

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