Fibrosis, Electrics and Genetics : Perspectives on Sinoatrial Node Disease

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  • Morris Gwilym M
    Institute of Cardiovascular Sciences, University of Manchester, Core Technology Facility Department of Cardiology, The Royal Melbourne Hospital
  • Kalman Jonathan M
    Department of Cardiology, The Royal Melbourne Hospital Department of Medicine, Melbourne University

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タイトル別名
  • Fibrosis, Electrics and Genetics
  • – Perspectives on Sinoatrial Node Disease –

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The sinoatrial node (SAN) is the normal pacemaker of the heart. During a human lifetime it must initiate approximately 2 billion heartbeats and coordinate the cardiovascular response to our physiological and emotional demands. Disease of the SAN is common, and one of the leading indications for electronic pacemaker implantation. Advances in understanding the genetics and molecular mechanisms determining normal SAN function, and of the pathways controlling remodeling are revealing SAN disease to be heterogeneous. We review the contemporary concepts of SAN function, heart rate adaptation and SAN disease from the molecular level to clinical application. (Circ J 2014; 78: 1272–1282)

収録刊行物

  • Circulation Journal

    Circulation Journal 78 (6), 1272-1282, 2014

    一般社団法人 日本循環器学会

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