Evidence of Pulmonary Vascular Reverse Remodeling After Pulmonary Artery Banding Performed in Early Infancy in Patients With Congenital Heart Defects

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  • Masaki Naoki
    Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine
  • Saiki Yuriko
    Department of Molecular Pathology, Tohoku University Graduate School of Medicine
  • Endo Masato
    Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine
  • Maeda Kay
    Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine
  • Adachi Osamu
    Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine
  • Akiyama Masatoshi
    Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine
  • Kawamoto Shunsuke
    Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine
  • Saiki Yoshikatsu
    Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine

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<p>Background:Histomorphometric evidence of the effect of pulmonary artery banding (PAB) in infancy on pulmonary vascular reverse remodeling has not been fully described.</p><p>Methods and Results:We retrospectively reviewed 34 patients who underwent serial lung biopsies before and after PAB.Index of pulmonary vascular disease (IPVD) as a measure of the degree of progression of pulmonary arteriopathy significantly decreased after PAB (1.22±0.25 at 1st and 1.13±0.21 at 2nd biopsy, P=0.04). Additionally,DR=100 µmas an indicator of medial thickness of pulmonary arteries significantly decreased after PAB (15.6±3.7 at 1st and 11.4±2.6 at 2nd biopsy, P<0.0001). Patients were divided into 3 groups by age at PAB: <3 months (Group 1), between 3 and 6 months (Group 2), and >6 months (Group 3). The average secondDR=100 µmof groups 1 and 2 was significantly lower than that of group 3 (11.1±2.2 and 9.8±2.0 vs. 14.9±2.8, respectively; P<0.0001). Additionally, the second IPVD was also significantly lower in groups 1 and 2 than in group 3 (1.1±0.2 and 1.1±0.2 vs. 1.3±0.4, respectively; P=0.02).</p><p>Conclusions:Histomorphometric evidence of post-PAB pulmonary vascular reverse remodeling is robust. The magnitude of vascular reversibility is pronounced when PAB is performed before 6 months of age.</p>

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  • Circulation Journal

    Circulation Journal 82 (3), 684-690, 2018

    一般社団法人 日本循環器学会

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