Impacts of Surgically Performed Renal Denervation on the Cardiovascular and Electrophysiological Variables in the Chronic Atrioventricular Block Dogs　– Comparison With Those of Amiodarone Treatment –

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  • Wada Takeshi
    Department of Pharmacology, Faculty of Medicine, Toho University Department of Cardiology, Juntendo University School of Medicine
  • Ohara Hiroshi
    Division of Cardiovascular Medicine, Department of Internal Medicine, Toho University Faculty of Medicine
  • Nakamura Yuji
    Department of Pharmacology, Faculty of Medicine, Toho University
  • Yokoyama Hirofumi
    Department of Pharmacology, Faculty of Medicine, Toho University
  • Cao Xin
    Department of Pharmacology, Faculty of Medicine, Toho University
  • Izumi-Nakaseko Hiroko
    Department of Pharmacology, Faculty of Medicine, Toho University
  • Ando Kentaro
    Department of Pharmacology, Faculty of Medicine, Toho University
  • Murakoshi Nobuyuki
    Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba
  • Sato Akira
    Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba
  • Aonuma Kazutaka
    Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba
  • Takahara Akira
    Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University
  • Nakazato Yuji
    Department of Cardiology, Juntendo University School of Medicine, Urayasu Hospital Heart Center
  • Sugiyama Atsushi
    Department of Pharmacology, Faculty of Medicine, Toho University

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Background:In order to begin to precisely clarify the impact of renal denervation on the blood pressure, atrial fibrillation and ventricular tachyarrhythmias, in addition to proarrhythmic potential, its cardiovascular effects were assessed by using the chronic complete atrioventricular block dogs.Methods and Results:Cardiohemodynamic and electrophysiological effects, together with neurohumoral factors and/or electrolytes, were assessed before and 4 weeks after either renal denervation (n=5) or amiodarone treatment (n=6). Amiodarone hydrochloride was given orally to the animals every day in a dose of 200 mg/day for the first 7 days followed by 100 mg/day for the following 21 days. The renal denervation decreased the systolic pressure, idioventricular rate, prolonged ventricular effective refractory period, and slightly suppressed the adrenergic tone and the renin-angiotensin-aldosterone system, but hardly affected the atrial effective refractory period and terminal repolarization period. Amiodarone prolonged the atrial effective refractory period, whereas no significant change was detected in the other variables.Conclusions:Surgically performed renal denervation may possess the anti-ventricular tachyarrhythmic rather than anti-atrial fibrillatory potentials, and it also modestly decreased the blood pressure. Thus, currently obtained information may be used as guidance for better understanding the utility and limitation of renal denervation against various types of cardiovascular diseases. (Circ J 2016; 80: 1556–1563)

収録刊行物

  • Circulation Journal

    Circulation Journal 80 (7), 1556-1563, 2016

    一般社団法人 日本循環器学会

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