FOCUS REVIEWS ON THE HIPPO PATHWAY : Hippo Signaling in the Heart : Non-Canonical Pathways Impact Growth, Survival and Function

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  • Re Dominic P. Del
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, Rutgers-New Jersey Medical School

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  • Hippo Signaling in the Heart　– Non-Canonical Pathways Impact Growth, Survival and Function –

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Initially identified inDrosophila melanogaster, the Hippo signaling pathway regulates organ size through modulation of cell proliferation, survival and differentiation. This pathway is evolutionarily conserved and canonical signaling involves a kinase cascade that phosphorylates and inhibits the downstream effector Yes-associated protein (YAP). Recent research has demonstrated a fundamental role of Hippo signaling in cardiac development, homeostasis, injury and regeneration, and remains the subject of intense investigation. However, 2 prominent members of this pathway, RASSF1A and Mst1, have been shown to influence heart function and stress responses through YAP-independent mechanisms. This review summarizes non-canonical targets of RASSF1A and Mst1 and discusses their role in the context of cardiac hypertrophy, autophagy, apoptosis and function. (Circ J 2016; 80: 1504–1510)

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  • Circulation Journal

    Circulation Journal 80 (7), 1504-1510, 2016

    一般社団法人 日本循環器学会

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