Five-Year Clinical Outcomes After Drug-Eluting Stent Implantation Following Rotational Atherectomy for Heavily Calcified Lesions
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- Jinnouchi Hiroyuki
- Division of Cardiovascular Medicine, Kokura Memorial Hospital
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- Kuramitsu Shoichi
- Division of Cardiovascular Medicine, Kokura Memorial Hospital
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- Shinozaki Tomohiro
- Department of Biostatistics, School of Public Health, the University of Tokyo
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- Hiromasa Takashi
- Division of Cardiovascular Medicine, Kokura Memorial Hospital
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- Kobayashi Yohei
- Division of Cardiovascular Medicine, Kokura Memorial Hospital
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- Takeji Yasuaki
- Division of Cardiovascular Medicine, Kokura Memorial Hospital
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- Miura Mizuki
- Division of Cardiovascular Medicine, Kokura Memorial Hospital
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- Masuda Hisaki
- Division of Cardiovascular Medicine, Kokura Memorial Hospital
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- Matsumura Yukiko
- Division of Cardiovascular Medicine, Kokura Memorial Hospital
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- Yamaji Yuhei
- Division of Cardiovascular Medicine, Kokura Memorial Hospital
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- Sakakura Kenichi
- Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University
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- Domei Takenori
- Division of Cardiovascular Medicine, Kokura Memorial Hospital
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- Soga Yoshimitsu
- Division of Cardiovascular Medicine, Kokura Memorial Hospital
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- Hyodo Makoto
- Division of Cardiovascular Medicine, Kokura Memorial Hospital
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- Shirai Shinichi
- Division of Cardiovascular Medicine, Kokura Memorial Hospital
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- Ando Kenji
- Division of Cardiovascular Medicine, Kokura Memorial Hospital
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<p>Background:Percutaneous coronary intervention for heavily calcified lesions requires rotational atherectomy (RA). Long-term clinical outcomes after drug-eluting stent (DES) implantation following (RA) for heavily calcified lesions remain unclear. We assessed 5-year clinical outcomes after DES implantation following RA.</p><p>Methods and Results:Between March 2006 and September 2011, 219 consecutive patients with 219 lesions treated with DES following RA, were retrospectively enrolled. The cumulative 5-year incidence of target-lesion revascularization (TLR) and definite stent thrombosis (ST) were assessed. The cumulative incidence of TLR within (≤) the first year was 18.6%. Late TLR beyond (>) 1 year continued to occur at 1.9% per year without a decrease in the rate (5-year incidence, 26.0%). The cumulative incidence of definite ST at 30 days, 1 and 5 years was 0.9%, 2.3% and 2.9%, respectively. The annual rate of definite ST beyond 1 year was 0.15%. On multivariate analysis, the significant predictor of TLR within 1 year was use of first-generation DES (hazard ratio [HR], 2.09; 95% CI: 1.10–4.03, P=0.02) and that of TLR beyond 1 year was hemodialysis (HR, 3.29; 95% CI: 1.06–10.55, P=0.04).</p><p>Conclusions:Late TLR beyond 1 year continued to occur up to 5 years at a constant annual incidence, whereas very late ST was rare. Careful long-term clinical follow-up is continually needed in patients who have already received DES following RA for heavily calcified lesions.</p>
収録刊行物
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- Circulation Journal
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Circulation Journal 82 (4), 983-991, 2018
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390001205108947328
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- NII論文ID
- 130006528541
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL書誌ID
- 028895001
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- PubMed
- 28890526
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
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