Cyclic Voltammetric Evaluation of Affinity of Mold with 9-Straight Chain Alkylated Acridine Derivatives with Antifungal Activity

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  • YANO Jun
    Department of Food Science and Technology, Faculty of Engineering, Toa University
  • SAKIHARA Akitoshi
    Department of Food Science and Technology, Faculty of Engineering, Toa University
  • YONEMITU Tadashi
    Department of Industrial Chemistry, Faculty of Engineering, Kyushu Sangyo University
  • TORII Akiyoshi
    Department of Industrial Chemistry, Kurume National College of Technology
  • KAMATA Kichinosuke
    Department of Industrial Chemistry, Kurume National College of Technology
  • MATAKA Shuntaro
    Research Institute of Advanced Material Sciense and Department of Molecular Science and Technology, Graduate School of Engineering Sciences, Kyushu University
  • FUKATA Gouki
    Department of Food Science and Technology, Faculty of Engineering, Toa University

Bibliographic Information

Other Title
  • サイクリックボルタンメトリによる抗かび作用を有する9-直鎖アルキルアクリジン類とかびとの親和性の評価
  • サイクリックボルタンメトリ ニ ヨル コウカビ サヨウ オ ユウスル 9 チョクサ アルキルアクリジンルイ ト カ ビト ノ シンワセイ ノ ヒョウカ
  • Study on Relationship between Chemical Structure and Antifungal Activity Part 5
  • 化学構造と抗かび性に関する研究 (第5報)

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Description

The Correlation between the affinity of mold with 9-straight chain alkylated acridine derivatives and the antifungal activity was examined with an electrochemical method, cyclic voltammetry. 9-Methylacridine (MeAc), 9-ethylacridine (EtAc), 9-n-propylacridine (PrAc), 9-n-butylacridine (BtAc), 9-n-pentylacridine (PnAc), 9-n-hexylacridine (HxAc), 9-n-heptylacridine (HpAc) and 9-n-octylacridine (OcAc) were employed as the 9-straight chain alkylated acridine derivatives and Aspergillus niger was used as mold. The cyclic voltammograms (CVs) of the derivatives were measured using a mold-covered Pt plate electrode. The reversible redox current peaks due to the generation-disappearance of the anion radicals of the derivatives were observed in all the CVs. The adsorption current peaks significantly appeared in the CVs of PnAc. Furthermore, the reversible redox current peaks were directly proportional not to the square root of the scan rate, but to the scan rate. This meant that PnAc was adsorbed by the mold. Judging from the fact that PnAc has the highest antifungal activity, the adsorption of the 9-straight chain alkylated acridine derivatives to the mold was an important factor for the antifungal activity.

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