Biomedical Characteristics of Primate Placenta: Transfer of Gene-therapeutic Materials to Fetuses

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  • 霊長類胎盤構造の特徴:遺伝子治療薬剤の胎盤通過の視点から
  • レイチョウルイ タイバン コウゾウ ノ トクチョウ イデンシ チリョウ ヤクザイ ノ タイバン ツウカ ノ シテン カラ

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Gene therapy or DNA vaccination involves gene delivery systems and methods which influence on the efficacy and the risk of the gene transfer. Establishment of a monkey model to assess the efficiency and the safety of the materials is necessary, because monkeys have similar genomic nature, biomedical and immunological responses to those of humans.<br>Here we overview the structure of primate placenta, focusing on the maternofeto placental barrier to evaluate monkeys as an experimental model for gene transfer during pregnancy. Placentae of humans and monkeys are hemochorial type and have only one layer of trophoblast which contacts with maternal blood, while other conventional experimental animals (rats and mice) have two or three layers of the trophoblast. Thus, it is concluded that the monkey model is the most suitable to estimate the material transfer to fetuses through placenta.<br>We also showed gene transfer experiments on pregnant marmosets. In our study, GFP DNA/liposome vector was administered to marmosets at full term, and GFP DNA and GFP protein were both detected in fetal tissues. It indicates the necessity of careful administration of the liposome vectors during pregnancy and also suggests the feasibility of gene therapy and DNA vaccination to fetuses.

Journal

  • Primate Research

    Primate Research 17 (2), 51-61, 2001

    Primate Society of Japan

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