The Different Roles of 5-HT2 and 5-HT3 Receptors on Antinociceptive Effect of Paroxetine in Chemical Stimuli in Mice
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- Kesim Murat
- Department of Pharmacology, Karadeniz Technical University School of Medicine
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- Duman Erdem N.
- Department of Anesthesiology, Karadeniz Technical University School of Medicine
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- Kadioglu Mine
- Department of Pharmacology, Karadeniz Technical University School of Medicine
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- Yaris Ersin
- Department of Pharmacology, Karadeniz Technical University School of Medicine
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- Kalyoncu Nuri I.
- Department of Pharmacology, Karadeniz Technical University School of Medicine
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- Erciyes Nesrin
- Department of Anesthesiology, Karadeniz Technical University School of Medicine
書誌事項
- タイトル別名
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- Different Roles of 5 HT2 and 5 HT3 Receptors on Antinociceptive Effect of Paroxetine in Chemical Stimuli in Mice
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説明
Serotonin (5-HT) is known to be an important mediator in pain modulation. Some centrally acting agents, like selective serotonin reuptake inhibitors (SSRIs), modulate pain. Activation of the endogenous opioid mechanisms or potentiation of analgesic effect by serotonergic and/or noradrenergic pathways might be involved in antinociception of SSRIs. However, peripheral mechanisms of nociception are not clear. In this study, the antinociceptive effect of paroxetine, its interaction with the opioidergic system and serotonin receptors were tested using the writhing test in mice. Paroxetine (5, 10, 20 mg/kg) induced an antinociceptive effect following i.p. administration in writhing test. For the groups in which the antagonists were tested, the dose of paroxetine that caused a significant and equipotent analgesic effect similar to 0.5 mg/kg morphine was selected. Naloxone significantly antagonized the antinociceptive effects of both paroxetine and morphine in a similar pattern and magnitude. Ketanserin (5-HT2-receptor antagonist) or ondansetron (5-HT3-receptor antagonist) alone did not alter the nociceptive action of acetic acid. While the antinociceptive effect of paroxetine was highly potentiated by ketanserin, ondansetron reduced that antinociception. In conclusion, our results indicate that the antinociceptive effect of paroxetine mainly depends on central opioidergic and serotonergic mechanisms. Peripheral serotonergic mechanisms/receptors may contribute to this antinociceptive effect, especially by 5-HT3-receptor subtypes.<br>
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 97 (1), 61-66, 2005
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205175241984
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- NII論文ID
- 10025725244
- 130000074050
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- NII書誌ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 7228523
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- PubMed
- 15655293
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可