Pyrogens Enhance β-Endorphin Release in Hypothalamus and Trigger Fever That Can Be Attenuated by Buprenorphine
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- Tsai Shu-Ming
- Institute of Physiology, National Yang-Ming University Medical School
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- Lin Mao-Tsun
- Department of Medical Research, Chi-Mei Medical Center
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- Wang Jhi-Joung
- Department of Medical Research, Chi-Mei Medical Center
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- Huang Wu-Tein
- Department of Health Care Administration, Diwan University
書誌事項
- タイトル別名
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- Pyrogens Enhance .BETA.-Endorphin Release in Hypothalamus and Trigger Fever That Can Be Attenuated by Buprenorphine
- Pyrogens Enhance ベータ Endorphin Release in Hypothalamus and Trigger Fever That Can Be Attenuated by Buprenorphine
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抄録
At first, we investigated whether both β-endorphin release level in the hypothalamus and body temperature can be altered after intracerebroventricular (i.c.v.) injection of either lipopolysaccharide (LPS), interleukin-1β (IL-1β), or prostaglandin E2 (PGE2) in rats. It was found that in the rat, i.c.v. administration of either LPS (0.5 μg in 10 μl), IL-1β (10 ng in 10 μl), or PGE2 (200 ng in 10 μl), in addition to producing fever, upregulated the immunoreactivity of β-endorphin in the preoptic anterior hypothalamus of rat brain. Secondarily, we assessed whether the fever induced by either LPS, IL-1β, or PGE2 can be altered by pretreatment with buprenorphine (an opioid receptor antagonist). The results revealed that i.c.v. administration of buprenorphine (1 – 10 μg in 10 μl) alone had an insignificant effect on the body temperature. However, the fever induced by i.c.v. injection of either LPS, IL-1β, or PGE2 was significantly attenuated by pretreatment with i.c.v. injection of buprenorphine 1 h before the pyrogen injection in rats. The results suggest that pyrogens enhance β-endorphin release in the hypothalamus and trigger fever which can be attenuated by buprenorphine, an opioid receptor antagonist.<br>
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 93 (2), 155-162, 2003
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205175392512
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- NII論文ID
- 10012440152
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- NII書誌ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 6718125
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- PubMed
- 14578583
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可