α-Mangostin Induces Ca〔2+〕-ATPase-Dependent Apoptosis via Mitochondrial Pathway in PC12 Cells
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- Sato Ayumi
- Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University
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- Fujiwara Hironori
- Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University
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- Oku Hisae
- School of Pharmaceutical Sciences, Mukogawa Women’s University
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- Ishiguro Kyoko
- School of Pharmaceutical Sciences, Mukogawa Women’s University
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- Ohizumi Yasushi
- Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University
書誌事項
- タイトル別名
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- .ALPHA.-Mangostin Induces Ca2+-ATPase-Dependent Apoptosis via Mitochondrial Pathway in PC12 Cells
- アルファ Mangostin Induces Ca 2 ATPase Dependent Apoptosis via Mitochondrial Pathway in PC12 Cells
- α-Mangostin Induces Ca2+-ATPase-Dependent Apoptosis via Mitochondrial Pathway in PC12 Cells
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抄録
We investigated the cell death effects of eight xanthones on PC12 rat pheochromocytoma cells. Among these compounds, α-mangostin, from the fruit hull of Garcinia mangostana L., had the most potent effect with the EC50 value of 4 μM. α-Mangostin-treated PC12 cells demonstrated typical apoptotic DNA fragmentation and caspase-3 cleavage (equivalent to activation). The flow cytometric analysis indicated that this compound induced apoptosis in time-and concentration-dependent manners. α-Mangostin showed the features of the mitochondrial apoptotic pathway such as mitochondrial membrane depolarization and cytochrome c release. Furthermore, α-mangostin inhibited the sarco(endo)plasmic reticulum Ca2+-ATPase markedly. There was a correlation between the Ca2+-ATPase inhibitory effects and the apoptotic effects of the xanthone derivatives. On the other hand, c-Jun NH2-terminal kinase (JNK/SAPK), one of the signaling molecules of endoplasmic reticulum (ER) stress, was activated with α-mangostin treatment. These results suggest that α-mangostin inhibits Ca2+-ATPase to cause apoptosis through the mitochondorial pathway.<br>
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 95 (1), 33-40, 2004
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205175456512
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- NII論文ID
- 10013054384
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- NII書誌ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 6944390
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- PubMed
- 15153648
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
