Current Perspective: Convergence and Divergence, a Concept for Explaining Drug Actions
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- Watanabe Takehiko
- Department of Pharmacology, Tohoku University Graduate School of Medicine
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- Kamisaki Yoshinori
- Department of Pharmacology, Osaka University Graduate School of Dentistry
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- Timmerman Henk
- Department of Pharmacochemistry, Vrije Universiteit
書誌事項
- タイトル別名
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- Convergence and Divergence, a Concept for Explaining Drug Actions
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For the teaching and/or learning about drug actions and for the discovery and development of new drugs, it is important to understand how drugs act on living bodies. So far, there has been no clear description on the general principle of drug action in pharmacology textbooks. We propose two principles to depict the action mechanism of drugs. The first is that most, if not all, drugs act on proteins at the molecular level, that is, enzymes, receptors, ion channels, and transporters. The second is that a drug may cause divergent or convergent responses, resulting in changes of a physiological or pathological function of the human body. The concept of divergence and convergence can be used to explain the complex individuality of drug actions.<br>
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 96 (2), 95-100, 2004
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205175613056
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- NII論文ID
- 10014166444
- 130000074183
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- NII書誌ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 7120571
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- PubMed
- 15492469
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可