The Role of Nuclear Receptors During Neural Stem Cell Proliferation and Differentiation

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  • Katayama Kazufumi
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Science, Osaka University
  • Wada Koichiro
    Department of Pharmacology, Graduate School of Dentistry, Osaka University
  • Nakajima Atsushi
    The Third Department of Internal Medicine, Yokohama City University School of Medicine
  • Kamisaki Yoshinori
    Department of Pharmacology, Graduate School of Dentistry, Osaka University
  • Mayumi Tadanori
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Science, Osaka University

書誌事項

タイトル別名
  • Nuclear Receptors as Targets for Drug Development: The Role of Nuclear Receptors During Neural Stem Cell Proliferation and Differentiation
  • Role of Nuclear Receptors During Neural Stem Cell Proliferation and Differentiation

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The fate of stem cells, such as neural stem cells and hematopoietic stem cells, depends on strictly regulated signaling events including activation of nuclear receptors, resulting in subsequent gene induction. Recently, we demonstrated that PPARγ, a ligand-activated nuclear receptor, plays an important role in regulating the proliferation and differentiation of murine neural stem cell (NSC). NSC prepared from heterozygous PPARγ-deficient mouse exhibited a slower growth rate compared with that of wild-type mouse, which was also demonstrated in PPARγ-knockdown NSC that was generated by the lentiviral-vector-mediated RNA interference approach. These studies have important implications for understanding central nervous system functions and developing a therapy for neurodegenerative disorders. In this review, recent findings on stem cell biology, especially focusing on nuclear receptors in NSCs, including our current study, will be discussed.<br>

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