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- Hollenberg Morley D.
- Canadian Institutes of Health Research Proteinases and Inflammation Network, Endocrine-Diabetes, Smooth Muscle and Mucosal Inflammation Groups, Departments of Pharmacology & Therapeutics and Medicine, University of Calgary, Faculty of Medicine
書誌事項
- タイトル別名
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- Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs): Proteinases as Hormone-Like Signal Messengers: PARs and More
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抄録
Proteinases like thrombin and trypsin, long known for their ability to activate the coagulation cascade or to act as digestive enzymes for many protein targets, are now recognized as hormone-like regulators of cell function. These serine proteinases activate cell signaling by triggering a novel family of G-protein-coupled receptors, termed proteinase-activated receptors (PARs). This article summarizes the unique mechanisms involved in PAR activation and outlines the many different settings in which the PARs act to regulate tissue function. The PARs can be seen to play a role in inflammatory processes in large part via a neurogenic mechanism. Apart from activating PARs to cause their physiological effects in tissues, proteinases can also mediate cell signaling via a number of other mechanisms, including the activation of growth factor receptors, like the one for insulin. Thus, this article also points out the non-PAR mechanisms whereby proteinases can have hormone-like actions in cells and tissues.<br>
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 97 (1), 8-13, 2005
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205176171904
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- NII論文ID
- 10025724907
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- NII書誌ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 7228337
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- PubMed
- 15665444
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可