Current Topics in Pharmacological Research on Bone Metabolism: Inhibitory Effects of Bisphosphonates on the Differentiation and Activity of Osteoclasts

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  • Suzuki Keiko
    Department of Pharmacology, School of Dentistry, Showa University, Japan
  • Takeyama Sadaaki
    Division of Pharmacology, Department of Oral Biology, Tohoku University Graduate School of Dentistry, Japan
  • Sakai Yasushi
    Division of Physiology, School of Nursing and Rehabilitation Sciences, Showa University, Japan
  • Yamada Shoji
    Department of Pharmacology, School of Dentistry, Showa University, Japan
  • Shinoda Hisashi
    Division of Pharmacology, Department of Oral Biology, Tohoku University Graduate School of Dentistry, Japan

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  • Inhibitory Effects of Bisphosphonates on the Differentiation and Activity of Osteoclasts

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Abstract

Despite the extensive use of bisphosphonates (BPs) in the treatment of metabolic bone diseases associated with increased osteoclastic bone resorption, the precise mechanism of their action on bone metabolism is still unclear. To clarify at which stages of osteoclast differentiation and activation that BPs influence, we examined the osteoclasts generated from mononuclear precursors and osteoclasts in the calvaria by laser scanning confocal microscopy. The studies showed that BPs inhibit lipopolysaccharide- or parathyroid hormone-induced osteoclast differentiation, fusion, attachment, actin ring formation, and activation and that both β3 integrin and osteopontin have an important role in cytoskeletal rearrangements associated with cell attachment and resorption in osteoclasts.<br>

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