Ca〔2+〕-Dependent Inositol 1,4,5-Trisphosphate and Nitric Oxide Signaling in Cerebellar Neurons
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- Iino Masamitsu
- Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Japan
書誌事項
- タイトル別名
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- Ca2+-Dependent Inositol 1,4,5-Trisphosphate and Nitric Oxide Signaling in Cerebellar Neurons
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Intracellular Ca2+ signals are important for the regulation of synaptic functions in the central nervous system. In this review, I summarize findings of our recent studies on upstream and downstream Ca2+ signaling mechanisms in cerebellar synapses using novel molecular imaging methods. Inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release plays a pivotal role in central synapses. The visualization of IP3 at fine dendrites of Purkinje cells (PCs) using a fluorescent IP3 indicator showed that intracellular Ca2+ concentration has a stimulatory effect on phospholipase C activity, which catalyzes IP3 production. This indicates that metabotropic and ionotropic glutamate receptors collaborate to generate IP3 signals. Using a novel nitric oxide (NO) indicator, the spatial distribution of NO signals originating from parallel fiber (PF) terminals was visualized. Our results show that the NO signal decays steeply with distance from the site of production in the cerebellum and is dependent on PF stimulation frequency in a biphasic manner. NO released from PF terminals generated a synapse-specific long-term potentiation of PF-PC synapse when PF was stimulated at certain frequencies. These imaging studies clarified new aspects of the regulatory mechanisms of synaptic functions.<br>
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 100 (5), 538-544, 2006
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205176796544
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- NII論文ID
- 10018239654
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- NII書誌ID
- AA11806667
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- COI
- 1:STN:280:DC%2BD28zot1aksw%3D%3D
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 7963308
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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