Transcriptional Regulation of Neuronal Genes and Its Effect on Neural Functions: NAD-Dependent Histone Deacetylase SIRT1 (Sir2.ALPHA.)
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- Hisahara Shin
- Department of Pharmacology, Sapporo Medical University, School of Medicine Department of Neurology, Sapporo Medical University, School of Medicine
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- Chiba Susumu
- Department of Neurology, Sapporo Medical University, School of Medicine
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- Matsumoto Hiroyuki
- Department of Neurology, Sapporo Medical University, School of Medicine
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- Horio Yoshiyuki
- Department of Pharmacology, Sapporo Medical University, School of Medicine
Bibliographic Information
- Other Title
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- NAD-Dependent Histone Deacetylase SIRT1 (Sir2α)
- NAD Dependent Histone Deacetylase SIRT1 Sir2 アルファ
- Transcriptional Regulation of Neuronal Genes and Its Effect on Neural Functions: NAD-Dependent Histone Deacetylase SIRT1 (Sir2α)
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Description
Sir2 (silent information regulator 2) is an NAD-dependent deacetylase that is broadly conserved from bacteria to humans. It catalyzes a unique deacetylation reaction using NAD, and specific inhibitors and activators of its activity have been discovered. In yeast, Sir2 deacetylates histones and participates in transcription silencing and the suppression of recombination. Sir2 is also implicated in the regulation of aging, because its increased expression extends the lifespan of yeast and nematodes. Mammalian SIRT1 (Sir2α) is a member of the Sir2 family. Recently, SIRT1 was shown to interact with various transcription factors such as p53, forkhead transcription factor (FOXO) family proteins, and MyoD, and to participate in stress tolerance, differentiation, and development.<br>
Journal
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 98 (3), 200-204, 2005
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390001205176959744
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- NII Article ID
- 10025728609
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- NII Book ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL BIB ID
- 7368799
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- PubMed
- 16006743
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed