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- Sasa Masashi
- Hiroshima University, Japan Nagisa Hospital, Japan
書誌事項
- タイトル別名
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- A New Frontier in Epilepsy: Novel Antiepileptogenic Drugs
- New Frontier in Epilepsy Novel Antiepileptogenic Drugs
この論文をさがす
抄録
Epilepsy is a hetergenous syndrome characterized by recurrently and repeatedly occurring seizures. Although able to inhibit the epileptic seizures, the currently available antiepileptic drugs (AEDs) have no effects on epileptogenesis. Such AEDs should be classified as drugs against ictogenesis, which are transient events in ion and/or receptor-gated channels related with triggering to evoke seizures. Epileptogenesis involves long-term and histological/biochemical/physiological alterations formed in brain structures over a long period, ranging from months to years. This review focuses on the effects of AEDs on epileptogenesis and novel candidates of antiepileptogenic drugs using a genetically defined epilepsy model animal, the spontaneous epileptic rat (SER).<br>
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 100 (5), 487-494, 2006
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205177099776
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- NII論文ID
- 10018239249
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- NII書誌ID
- AA11806667
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- COI
- 1:STN:280:DC%2BD28zot1alsA%3D%3D
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 7963248
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可