Peripheral Antinociception by Carbamazepine in an Inflammatory Mechanical Hyperalgesia Model in the Rat: a New Target for Carbamazepine?
-
- Vuckovic Sonja
- Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Serbia and Montenegro
-
- Tomic Maja
- Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, Serbia and Montenegro
-
- Stepanovic-Petrovic Radica
- Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, Serbia and Montenegro
-
- Ugrešic Nenad
- Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, Serbia and Montenegro
-
- Prostran Milica
- Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Serbia and Montenegro
-
- Boškovic Bogdan
- Medical Military Academy, Serbia and Montenegro
この論文をさがす
抄録
This study investigated whether carbamazepine could produce local peripheral antinociception in a rat model of inflammatory mechanical hyperalgesia, and whether adenosine receptors are involved. Carbamazepine (100 – 1000 nmol/paw) coadministrated with a pro-inflammatory compound, concanavalin A, into the hind paw caused a significant dose- and time-dependent anti-hyperalgesia. Coadministration of caffeine (250 – 1000 nmol/paw), a nonselective adenosine-receptor antagonist, as well as DPCPX (10 – 30 nmol/paw), a selective adenosine A1-receptor antagonist, with carbamazepine, significantly depressed its anti-hyperalgesic effect. Drugs injected into the contralateral hind paw did not produce significant effects. These results suggest that carbamazepine produces local peripheral anti-hyperalgesia via peripheral adenosine A1 receptors.<br>
収録刊行物
-
- Journal of Pharmacological Sciences
-
Journal of Pharmacological Sciences 100 (4), 310-314, 2006
公益社団法人 日本薬理学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001205177641984
-
- NII論文ID
- 10018240041
-
- NII書誌ID
- AA11806667
-
- ISSN
- 13478648
- 13478613
-
- NDL書誌ID
- 7885000
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可