The Regulation of Bone Resorption in Tooth Formation and Eruption Processes in Mouse Alveolar Crest Devoid of Cathepsin K

DOI Web Site PubMed 被引用文献1件 参考文献63件
  • Okaji Masayo
    Department of Orthodontics, Graduate School of Biomedical Sciences, Nagasaki University Department of Dental Pharmacology, Graduate School of Biomedical Sciences, Nagasaki University
  • Sakai Hideaki
    Department of Dental Pharmacology, Graduate School of Biomedical Sciences, Nagasaki University
  • Sakai Eiko
    Department of Dental Pharmacology, Graduate School of Biomedical Sciences, Nagasaki University
  • Shibata Mitsue
    Department of Dental Pharmacology, Graduate School of Biomedical Sciences, Nagasaki University
  • Hashimoto Fumio
    Department of Orthodontics, Graduate School of Biomedical Sciences, Nagasaki University
  • Kobayashi Yasuhiro
    Department of Orthodontics, Graduate School of Biomedical Sciences, Nagasaki University
  • Yoshida Noriaki
    Department of Orthodontics, Graduate School of Biomedical Sciences, Nagasaki University
  • Okamoto Kuniaki
    Department of Dental Pharmacology, Graduate School of Biomedical Sciences, Nagasaki University
  • Yamamoto Kenji
    Department of Pharmacology, Graduate School of Dental Science, Kyushu University
  • Kato Yuzo
    Department of Dental Pharmacology, Graduate School of Biomedical Sciences, Nagasaki University

書誌事項

タイトル別名
  • Regulation of Bone Resorption in Tooth Formation and Eruption Processes in Mouse Alveolar Crest Devoid of Cathepsin K

この論文をさがす

抄録

Osteoclastic bone resorption has recently been implicated in the tooth formation and eruption in alveolar bone. Cathepsin K (CK) is a cysteine proteinase expressed predominantly in osteoclasts and is believed to play a critical role in degradation of bone matrix proteins. Here we present evidence that the alveolar bone resorption is essential for the tooth formation and that eruption proceeds normally in CK-deficient (CK−/−) mice. Radiographic and histological analyses revealed that the alveolar bone from these animals had no significant abnormalities during the tooth development between 5 and 28 days after birth. The tooth crown was normally erupted through the alveolar bone layer at 28 days after birth. The number of tartrate-resistant acid phosphatase-positive multinuclear cells in the alveolar bone around the tooth germ was apparently increased in 5-day-old CK−/− mice compared with age-matched littermates. More important, however, the immunohistochemical localization of matrix metalloproteinase-9 (MMP-9) was clearly increased in the CK−/− osteoclasts. In contrast, no significant difference in the immunoreactivity for cathepsin D was observed between the CK−/− osteoclasts and the wild-type ones. These results indicate that CK−/− osteoclasts are fully differentiated and are capable of degrading the organic phase of alveolar bone during the tooth formation and eruption, which may result from the compensatory action by MMP-9 increasingly expressed in the osteoclasts.<br>

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (63)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ