The Regulation of Bone Resorption in Tooth Formation and Eruption Processes in Mouse Alveolar Crest Devoid of Cathepsin K
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- Okaji Masayo
- Department of Orthodontics, Graduate School of Biomedical Sciences, Nagasaki University Department of Dental Pharmacology, Graduate School of Biomedical Sciences, Nagasaki University
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- Sakai Hideaki
- Department of Dental Pharmacology, Graduate School of Biomedical Sciences, Nagasaki University
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- Sakai Eiko
- Department of Dental Pharmacology, Graduate School of Biomedical Sciences, Nagasaki University
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- Shibata Mitsue
- Department of Dental Pharmacology, Graduate School of Biomedical Sciences, Nagasaki University
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- Hashimoto Fumio
- Department of Orthodontics, Graduate School of Biomedical Sciences, Nagasaki University
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- Kobayashi Yasuhiro
- Department of Orthodontics, Graduate School of Biomedical Sciences, Nagasaki University
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- Yoshida Noriaki
- Department of Orthodontics, Graduate School of Biomedical Sciences, Nagasaki University
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- Okamoto Kuniaki
- Department of Dental Pharmacology, Graduate School of Biomedical Sciences, Nagasaki University
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- Yamamoto Kenji
- Department of Pharmacology, Graduate School of Dental Science, Kyushu University
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- Kato Yuzo
- Department of Dental Pharmacology, Graduate School of Biomedical Sciences, Nagasaki University
書誌事項
- タイトル別名
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- Regulation of Bone Resorption in Tooth Formation and Eruption Processes in Mouse Alveolar Crest Devoid of Cathepsin K
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説明
Osteoclastic bone resorption has recently been implicated in the tooth formation and eruption in alveolar bone. Cathepsin K (CK) is a cysteine proteinase expressed predominantly in osteoclasts and is believed to play a critical role in degradation of bone matrix proteins. Here we present evidence that the alveolar bone resorption is essential for the tooth formation and that eruption proceeds normally in CK-deficient (CK−/−) mice. Radiographic and histological analyses revealed that the alveolar bone from these animals had no significant abnormalities during the tooth development between 5 and 28 days after birth. The tooth crown was normally erupted through the alveolar bone layer at 28 days after birth. The number of tartrate-resistant acid phosphatase-positive multinuclear cells in the alveolar bone around the tooth germ was apparently increased in 5-day-old CK−/− mice compared with age-matched littermates. More important, however, the immunohistochemical localization of matrix metalloproteinase-9 (MMP-9) was clearly increased in the CK−/− osteoclasts. In contrast, no significant difference in the immunoreactivity for cathepsin D was observed between the CK−/− osteoclasts and the wild-type ones. These results indicate that CK−/− osteoclasts are fully differentiated and are capable of degrading the organic phase of alveolar bone during the tooth formation and eruption, which may result from the compensatory action by MMP-9 increasingly expressed in the osteoclasts.<br>
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 91 (4), 285-294, 2003
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205177653120
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- NII論文ID
- 130000073687
- 30003472503
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- NII書誌ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 6510761
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- PubMed
- 12719657
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可