Antinociceptive Effects of Sodium Channel-Blocking Agents on Acute Pain in Mice

DOI Web Site PubMed 6 Citations 33 References
  • Sakaue Akiko
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University
  • Honda Motoko
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University
  • Tanabe Mitsuo
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University
  • Ono Hideki
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University

Search this article

Abstract

The effects of various sodium channel blocking agents on acute thermal and mechanical nociception, as assessed using the plantar and tail pressure tests, respectively, were compared with the effects of morphine. The drugs used were mexiletine, lidocaine, carbamazepine, phenytoin, eperisone, tolperisone, and zonisamide. The sodium channel blocking agents exhibited a rather preferential elevation of the threshold for thermal nociception. By contrast, morphine produced similar analgesic effects on thermal and mechanical nociception. In the sciatic nerve isolated from mice, mexiletine, lidocaine, eperisone, and tolperisone impaired the propagation of low frequency action potentials (evoked at 0.2 Hz). Carbamazepine, phenytoin, and zonisamide generated a more frequency-dependent local anesthetic action with their obvious effects on higher frequency action potentials (evoked at 5 and/or 10 Hz). Our results show that sodium channel blocking agents have a preferential antinociceptive action against thermal stimulation that is likely to be attributed to their local anesthetic action.<br>

Journal

Citations (6)*help

See more

References(33)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top