Notable Functions of Branched Chain Amino Acids as Biological Regulators
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- Yoshizawa Fumiaki
- Department of Bioproductive Science, Faculty of Agriculture, Utsunomiya University, Japan
書誌事項
- タイトル別名
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- New Therapeutic Strategy for Amino Acid Medicine:<BR>Notable Functions of Branched Chain Amino Acids as Biological Regulators
- New Therapeutic Strategy for Amino Acid Medicine: Notable Functions of Branched Chain Amino Acids as Biological Regulators
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The branched chain amino acids (BCAAs) leucine, isoleucine, and valine are the most abundant of the essential amino acids. BCAAs have recently been recognized as having functions other than simple nutrition. The importance of BCAAs as nutrient regulators in protein synthesis was recognized over 20 years ago. Leucine is the most potent of the BCAAs in stimulating muscle protein synthesis, while isoleucine and valine are much less effective. The signaling action of leucine in protein synthesis has been well studied, and the mechanisms are currently under investigation. However, the pharmacological effects of isoleucine and valine have not been clarified. It has recently been reported that, among the BCAAs, leucine and isoleucine act as signals in glucose metabolism. We revealed that isoleucine stimulates both glucose uptake in the muscle and whole body glucose oxidation, in addition to depressing gluconeogenesis in the liver, thereby leading to a hypoglycemic effect in rats. Based on these results, we speculate that isoleucine signaling accelerates catabolism of incorporated glucose for energy production and consumption.
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 118 (2), 149-155, 2012
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205178017152
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- NII論文ID
- 10030454606
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- NII書誌ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 023439375
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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