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- 小林 孝志
- 千葉大学医学部附属病院皮膚科
書誌事項
- タイトル別名
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- Role of matrix metalloproteinase-9 expression on cutaneous inflammation: Possible treatment by leptomycin B application
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説明
Matrix metalloproteinase-9 has been suggested to play many roles in the inflammation including bullous disease, tumor invasion and metastasis, ultraviolet (UV) B-irradiated dermatosis, and dyskeratosis. We previously showed the upregulation of MMP-9 transcripts due to KRE-M9 element in the MMP-9 promoter in the differentiation of keratinocytes.<BR>Recently, much attention has been paid to leptomycin B (LMB), a modulator for trafficking a variety of transcription-related proteins from nucleus to cytoplasm.<BR>By the addition of LMB for kertinocytes in culture, MMP-9 secretions were reduced in comparison with MMP-2, even in the up-regulations of MMP-9 expression in high calcium or in the addition of transforming growth factor-β, both of which cause the differentiation of keratinocytes, and in the additions of tumor necrosis factor-α or interleukin-1α, inflammatory and apoptotic cytokines. In addition, KRE-M9 as well as other elements including 12-o-tetradecanoyl-o-phorbol-13-acetate responsive element was shown to be responsible for the reduced MMP-9 transcription by LMB.<BR>Topical applications of LMB on the murine skin after UVB irradiation prevented the skin from the dyskeratosis and from the infiltrates of inflammatory cells.<BR>These results indicate that the applications of LMB and of its derivatives could be a useful remedy for many pathological conditions in which MMP-9 are involved.
収録刊行物
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- 炎症・再生
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炎症・再生 24 (5), 578-583, 2004
一般社団法人 日本炎症・再生医学会
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詳細情報 詳細情報について
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- CRID
- 1390001205178051456
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- NII論文ID
- 10026498599
- 10024242508
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- NII書誌ID
- AA11508953
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- COI
- 1:CAS:528:DC%2BD2cXpvFansb4%3D
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- ISSN
- 18805795
- 13468022
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可