皮膚の炎症性疾患におけるｍａｔｒｉｘ　ｍｅｔａｌｌｏｐｒｏｔｅｉｎａｓｅ‐９の役割―Ｌｅｐｔｏｍｙｃｉｎ　Ｂ投与による治療の可能性について―

DOI 被引用文献1件 参考文献30件

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  • Role of matrix metalloproteinase-9 expression on cutaneous inflammation: Possible treatment by leptomycin B application

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Matrix metalloproteinase-9 has been suggested to play many roles in the inflammation including bullous disease, tumor invasion and metastasis, ultraviolet (UV) B-irradiated dermatosis, and dyskeratosis. We previously showed the upregulation of MMP-9 transcripts due to KRE-M9 element in the MMP-9 promoter in the differentiation of keratinocytes.<BR>Recently, much attention has been paid to leptomycin B (LMB), a modulator for trafficking a variety of transcription-related proteins from nucleus to cytoplasm.<BR>By the addition of LMB for kertinocytes in culture, MMP-9 secretions were reduced in comparison with MMP-2, even in the up-regulations of MMP-9 expression in high calcium or in the addition of transforming growth factor-β, both of which cause the differentiation of keratinocytes, and in the additions of tumor necrosis factor-α or interleukin-1α, inflammatory and apoptotic cytokines. In addition, KRE-M9 as well as other elements including 12-o-tetradecanoyl-o-phorbol-13-acetate responsive element was shown to be responsible for the reduced MMP-9 transcription by LMB.<BR>Topical applications of LMB on the murine skin after UVB irradiation prevented the skin from the dyskeratosis and from the infiltrates of inflammatory cells.<BR>These results indicate that the applications of LMB and of its derivatives could be a useful remedy for many pathological conditions in which MMP-9 are involved.

収録刊行物

  • 炎症・再生

    炎症・再生 24 (5), 578-583, 2004

    一般社団法人 日本炎症・再生医学会

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