New Frontiers in Gut Nutrient Sensor Research: Monosodium L-Glutamate Added to a High-Energy, High-Protein Liquid Diet Promotes Gastric Emptying: a Possible Therapy for Patients With Functional Dyspepsia
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- Kusano Motoyasu
- Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Japan
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- Zai Hiroaki
- Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan
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- Hosaka Hiroko
- Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan
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- Shimoyama Yasuyuki
- Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Japan
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- Nagoshi Atsuto
- Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan
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- Maeda Masaki
- Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan
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- Kawamura Osamu
- Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan
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- Mori Masatomo
- Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan
Bibliographic Information
- Other Title
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- Monosodium L-glutamate added to a high-energy, high-protein liquid diet promotes gastric emptying: a possible therapy for patients with functional dyspepsia
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Abstract
Functional dyspepsia is a clinical syndrome that features abdominal symptoms centered in the upper abdomen without an organic basis. Three possible mechanisms of gastric dysfunction could be related to functional dyspepsia: 1) delayed gastric emptying, 2) impaired gastric accommodation to food intake, and 3) hypersensitivity to gastric distention. Delayed gastric emptying has been suggested to lead to prolonged antral distension that causes dyspeptic symptoms. Delayed gastric emptying is therefore a focal point of debate about anorexia caused by dyspepsia, and prokinetic agents are often administered in Japan for its treatment. Recently, we found that addition of monosodium L-glutamate (MSG) to a high-energy liquid diet rich in casein promoted gastric emptying in healthy men. Therefore, another potential method to improve delayed gastric emptying could be enhancement of chemosensors that activate the autonomic nervous system innervating the gastrointestinal tract. In conclusion, enrichment with glutamate promoted gastric emptying after intake of a high-protein meal, suggesting that free glutamate is important for protein digestion and that MSG may be helpful for management of delayed gastric emptying in patients with functional dyspepsia.
Journal
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 112 (1), 33-36, 2010
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390001205178374272
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- NII Article ID
- 10027908481
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- NII Book ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL BIB ID
- 10524673
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed