LAT1 Is a Central Transporter of Essential Amino Acids in Human Umbilical Vein Endothelial Cells

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  • Hayashi Keitaro
    Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Japan
  • Jutabha Promsuk
    Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Japan
  • Kamai Takao
    Department of Urology, Dokkyo Medical University School of Medicine, Japan
  • Endou Hitoshi
    J-Pharma Co., Ltd., Japan
  • Anzai Naohiko
    Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Japan

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  • LAT1 is a central transporter of essential amino acid in human umbilical vein endothelial cells

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Abstract

Endothelial cell proliferation supporting angiogenesis requires sufficient nutrient supply because of facilitated intracellular metabolism. However, little is known about the mechanism for the promotion of nutrient incorporation in proliferating endothelial cells. Here we show that L-type amino acid transporter 1 (LAT1) is a major transporter of essential amino acids in human umbilical vein endothelial cells (HUVECs). Growing HUVECs express a certain level of LAT1. A LAT1-specific inhibitor suppressed leucine uptake, cell proliferation, and tube formation of HUVECs. Therefore, LAT1 acts to support effective uptake of amino acids, which is critical for the optimal function of HUVECs for angiogenesis.

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