Inhibition of Untransformed Prostaglandin H2 Production and Stretch-Induced Contraction of Rabbit Pulmonary Arteries by Indoxam, a Selective Secretory Phospholipase A2 Inhibitor
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- Tanabe Yoshiyuki
- Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Iwate Medical University, Japan Department of Cellular and Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Japan
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- Saito Maki
- Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Iwate Medical University, Japan
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- Morikawa Yuki
- Department of Cellular and Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Japan
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- Kamataki Akihisa
- Department of Pathology, School of Medicine, Iwate Medical University, Japan
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- Sawai Takashi
- Department of Pathology, School of Medicine, Iwate Medical University, Japan
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- Hirose Masamichi
- Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Iwate Medical University, Japan
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- Nakayama Koichi
- Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Iwate Medical University, Japan Department of Cellular and Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Japan
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Abstract
Involvement of secretory phospholipase A2 (sPLA2) in the stretch-induced production of untransformed prostaglandin H2 (PGH2) in the endothelium of rabbit pulmonary arteries was investigated. The stretch-induced contraction was significantly inhibited by indoxam, a selective inhibitor for sPLA2, and NS-398, a selective inhibitor for cyclooxygenase-2 (COX-2). Indoxam inhibited the RGD-sensitive-integrin–independent production of untransformed PGH2, but did not affect the RGD-sensitive-integrin–dependent production of thromboxane A2 (TXA2). These results suggest that the stretch-induced contraction and untransformed PGH2 production was mediated by sPLA2–COX-2 pathway, making it a new possible target for pharmacological intervention of pulmonary artery contractility.
Journal
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 115 (4), 525-531, 2011
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390001205178585728
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- NII Article ID
- 10029893573
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- NII Book ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL BIB ID
- 11049342
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed
