Effect of Cigarette Smoke Components on Vascular Smooth Muscle Cell Migration Toward Platelet-Derived Growth Factor BB

DOI Web Site PubMed 被引用文献3件 参考文献26件
  • Yoshiyama Shinji
    Department of Molecular and Cellular Pharmacology, Gunma University Graduate School of Medicine, Japan
  • Horinouchi Takahiro
    Department of Cellular Pharmacology, Hokkaido University Graduate School of Medicine, Japan
  • Miwa Soichi
    Department of Cellular Pharmacology, Hokkaido University Graduate School of Medicine, Japan
  • Wang Hong Hui
    Department of Molecular and Cellular Pharmacology, Gunma University Graduate School of Medicine, Japan
  • Kohama Kazuhiro
    Department of Molecular and Cellular Pharmacology, Gunma University Graduate School of Medicine, Japan
  • Nakamura Akio
    Department of Molecular and Cellular Pharmacology, Gunma University Graduate School of Medicine, Japan

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Cigarette smoking is one of the factors causing accumulation of vascular smooth muscle cells (VSMCs) in atherosclerotic plaques. Changes in cell migration toward platelet-derived growth factor BB were investigated using a Boyden chamber after 48-h preincubation of GBaSM-4 VSMCs with nicotine or nicotine-free cigarette smoke extract (CSE). A nicotine concentration of 0.1 μM maximally promoted cell migration; 0.1% CSE also promoted cell migration, while high CSE concentrations damaged GBaSM-4 cells. Fetal bovine serum (FBS) long-depletion induced decrease in migration of GBaSM-4 cells. Our results suggest that nicotine and some CSE components can induce GBaSM-4 cell migration.

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