書誌事項
- タイトル別名
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- MCP-1-CCR2 in renal fibrosis
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説明
Studies of chemokines and their cognate receptors have shed light on the detailed molecular mechanisms of leukocyte trafficking and activation in various inflammatory diseases including renal ones. Chemokine receptors expressed on renal resident cells might be involved in proliferation, proteinuria and fibrogenesis. Novel biological functions of chemokines would expand their universe beyond chemotaxis and activation of inflammatory cells in renal diseases. Importantly, MCP-1 and its cognate receptor CCR2 are now considered to contribute to progressive renal fibrosis, which is a hallmark of progressive renal diseases despite their etiologies, including diabetic nephropathy. The selective intervention of MCP-1-CCR2 via the administration of anti-MCP-1 neutralizing antibodies, CCR2 antagonists and the MCP-1 mutant ameliorated progressive renal fibrosis by resulting in decrease in the deposit of type I collagen and in reduced expression of TGF-β. This MCP-1-CCR2-dependent loop for progressive renal fibrosis was confirmed in CCR2 gene targeted mice. These findings suggest that the therapeutic strategy of blocking MCP-1-CCR2 may prove beneficial for progressive renal fibrosis.
収録刊行物
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- 炎症・再生
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炎症・再生 24 (5), 567-572, 2004
一般社団法人 日本炎症・再生医学会
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詳細情報 詳細情報について
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- CRID
- 1390001205178607232
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- NII論文ID
- 10026498566
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- NII書誌ID
- AA11508953
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- COI
- 1:CAS:528:DC%2BD2cXpvFansLY%3D
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- ISSN
- 18805795
- 13468022
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
