Identification of Cells Expressing Cyclooxygenase-2 in Response to Interleukin-1.BETA. in Rat Aortae
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- Nakano Tomoyuki
- Department of Environmental and Preventive Medicine, Hyogo College of Medicine, Japan
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- Wakabayashi Ichiro
- Department of Environmental and Preventive Medicine, Hyogo College of Medicine, Japan
Bibliographic Information
- Other Title
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- Identification of cells expressing cyclooxygenase-2 in response to interleukin-1β in rat aortae
- Identification of cells expressing cyclooxygenase 2 in response to interleukin 1 v in rat aortae
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Abstract
Localization of cyclooxygenase-2 (COX-2) in rat aortae was investigated. In endothelium-intact aortic strips stimulated with interleukin-1β (IL-1β), COX-2 was detected in adventitial fibroblasts and macrophages but not in tunica media. IL-1β−induced COX-2 expression was also detected in medial smooth muscle cells of endothelium-denuded aortae and cultured rat aortic smooth muscle cells. IL-1β−induced COX-2 expression in all of the above cells was abolished in the presence of U0126, an inhibitor of extracellular signal-regulated kinases (ERK). Thus, IL-1β induces COX-2 through the ERK-mediated pathway in adventitial fibroblasts and macrophages of healthy aortae; and in addition, medial smooth muscle cells are also responsible for COX-2 expression in remodeled aortae.
Journal
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 113 (1), 84-88, 2010
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390001205178636672
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- NII Article ID
- 130000253405
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- NII Book ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL BIB ID
- 10677000
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed