Direct Effects of Esmolol and Landiolol on Cardiac Function, Coronary Vasoactivity, and Ventricular Electrophysiology in Guinea-Pig Hearts
-
- Shibata Shigehiro
- Department of Cell Physiology, Akita University Graduate School of Medicine, Japan
-
- Okamoto Yosuke
- Department of Cell Physiology, Akita University Graduate School of Medicine, Japan
-
- Endo Shigeatsu
- Department of Critical Care Medicine, Iwate Medical University, Japan
-
- Ono Kyoichi
- Department of Cell Physiology, Akita University Graduate School of Medicine, Japan
書誌事項
- 公開日
- 2012
- 資源種別
- journal article
- DOI
-
- 10.1254/jphs.11202fp
- 公開者
- 公益社団法人 日本薬理学会
この論文をさがす
説明
The ultra-short acting, selective β1-adrenergic antagonists landiolol and esmolol are widely used perioperatively; however, little is known about their acute direct actions on the heart. The current study utilized the Langendorff perfused heart system to measure changes in cardiac function and hemodynamics in response to each drug. Furthermore, electrophysiological analysis was performed on isolated ventricular myocytes. Direct application of esmolol significantly decreased systolic left ventricular pressure and heart rate at concentrations > 10 μM, while it dose-dependently increased coronary perfusion pressure. Esmolol also shortened the action potential duration (APD) in a concentration-dependent manner, an action maintained even when the delayed rectifier K+ current or ATP sensitive K+ current was blocked. Moreover, esmolol inhibited both the inward rectifier K+ current (IK1) and the L-type Ca2+ current (ICaL) and increased the outward current dose-dependently. In contrast, landiolol had minimal cardiac effects. In the Kyoto Model computer simulation, inhibition of either IK1 or ICaL alone failed to shorten the APD; however, an additional increase in the time-independent outward current caused shortening of the APD, equal to that induced by esmolol. In conclusion, esmolol directly inhibits cardiac performance significantly more so than landiolol, an effect revealed to be at least in part mediated by esmolol-induced APD shortening.
収録刊行物
-
- Journal of Pharmacological Sciences
-
Journal of Pharmacological Sciences 118 (2), 255-265, 2012
公益社団法人 日本薬理学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001205178703232
-
- NII論文ID
- 10030455076
-
- NII書誌ID
- AA11806667
-
- ISSN
- 13478648
- 13478613
-
- NDL書誌ID
- 023439493
-
- PubMed
- 22293301
-
- 本文言語コード
- en
-
- 資料種別
- journal article
-
- データソース種別
-
- JaLC
- NDLサーチ
- Crossref
- CiNii Articles
- KAKEN
- OpenAIRE
-
- 抄録ライセンスフラグ
- 使用不可
