Oral administration of curcumin suppresses production of matrix metalloproteinase (MMP)-1 and MMP-3 to ameliorate collagen-induced arthritis: inhibition of the PKCδ/JNK/c-Jun pathway
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- Mun Se Hwan
- College of Medicine, Konkuk University, Korea
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- Kim Hyuk Soon
- College of Medicine, Konkuk University, Korea
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- Kim Jie Wan
- College of Medicine, Konkuk University, Korea
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- Ko Na Young
- College of Medicine, Konkuk University, Korea
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- Kim Do Kyun
- College of Medicine, Konkuk University, Korea
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- Lee Beob Yi
- College of Medicine, Konkuk University, Korea
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- Kim Bokyung
- College of Medicine, Konkuk University, Korea
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- Won Hyung Sik
- College of Biomedical & Health Science, Konkuk University, Korea
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- Shin Hwa-Sup
- College of Biomedical & Health Science, Konkuk University, Korea
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- Han Jeung-Whan
- College of Pharmacy, Sungkyunkwan University, Korea
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- Lee Hoi Young
- College of Medicine, Konyang University, Korea
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- Kim Young Mi
- College of Pharmacy, Duksung Women’s University, Korea
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- Choi Wahn Soo
- College of Medicine, Konkuk University, Korea
書誌事項
- タイトル別名
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- Oral Administration of Curcumin Suppresses Production of Matrix Metalloproteinase (MMP)-1 and MMP-3 to Ameliorate Collagen-Induced Arthritis: Inhibition of the PKC.DELTA./JNK/c-Jun Pathway
- Oral administration of curcumin suppresses production of matrix metalloproteinase MMP 1 and MMP 3 to ameliorate collagen induced arthritis inhibition of the PKC d JNK c Jun pathway
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We investigated whether oral administration of curcumin suppressed type II collagen–induced arthritis (CIA) in mice and its effect and mechanism on matrix metalloproteinase (MMP)-1 and MMP-3 production in CIA mice, RA fibroblast-like synoviocytes (FLS), and chondrocytes. CIA in mice was suppressed by oral administration of curcumin in a dose-dependent manner. Macroscopic observations were confirmed by histological examinations. Histological changes including infiltration of immune cells, synovial hyperplasia, cartilage destruction, and bone erosion in the hind paw sections were extensively suppressed by curcumin. The histological scores were consistent with clinical arthritis indexes. Production of MMP-1 and MMP-3 were inhibited by curcumin in CIA hind paw sections and tumor necrosis factor (TNF)-α–stimulated FLS and chondrocytes in a dose-dependent manner. As for the mechanism, curcumin inhibited activating phosphorylation of protein kinase Cδ (PKCδ) in CIA, FLS, and chondrocytes. Curcumin also suppressed the JNK and c-Jun activation in those cells. This study suggests that the suppression of MMP-1 and MMP-3 production by curcumin in CIA is mediated through the inhibition of PKCδ and the JNK/c-Jun signaling pathway.<br>
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 111 (1), 13-21, 2009
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205178990720
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- NII論文ID
- 10025738463
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- NII書誌ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 10370111
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 使用不可